Infect Chemother.
2006 Dec;38(6):398-402.
A Case of Cytomegalovirus Enterocolitis and Jejunal Perforation During Immune Reconstitution with Highly Active Antiretroviral Treatment
- Affiliations
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- 1Department of Internal Medicine, National Medical Center, Seoul, Korea. sdesdk@kornet.net
- 2Department of General Surgery, National Medical Center, Seoul, Korea.
Abstract
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Immune reconstitution syndrome (IRS) in HIV-infected patients is an adverse consequence of the restoration of pathogen-specific immune responses during the initial months of highly active antiretroviral treatment(HAART). Previously subclinical infections are unmasked or pre-existing opportunistic infections clinically deteriorate as host immunopathological inflammatory responses are switched on. While the eye is the area where Cytomegalovirus(CMV)-associated IRS occurs most often in patients with AIDS, it also can present with intestinal or pulmonary involvement. We present a case report of an HIV-infected patient in whom CMV enterocolitis and jejunal perforation developed after HAART.