Korean J Pediatr.
2014 Dec;57(12):526-532. 10.3345/kjp.2014.57.12.526.
Associations of matrix metalloproteinase (MMP)-8, MMP-9, and their inhibitor, tissue inhibitor of metalloproteinase-1, with obesity-related biomarkers in apparently healthy adolescent boys
- Affiliations
-
- 1Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.
- 2Department of Medicine, The Graduate School, Yonsei University, Seoul, Korea.
- 3Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea.
- 4Department of Biotechnology, The Catholic University of Korea, Bucheon St. Mary's Hospital, Bucheon, Korea.
- 5Department of Pediatrics, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Korea.
- 6Department of Pediatrics, National Medical Center, Seoul, Korea. hyejungshin@empas.com
- KMID: 2284642
- DOI: http://doi.org/10.3345/kjp.2014.57.12.526
Abstract
- PURPOSE
Matrix metalloproteinases (MMPs) have been implicated in atherosclerosis, and therefore, are considered risk factors for metabolic dysfunction in adults. However, there is little data on circulating levels of MMPs and tissue inhibitors of MMPs (TIMPs) with regard to obesity-related biomarkers in the general adolescent population. In the present study, we determined the associations of MMP-8, MMP-9, and TIMP-1 levels and MMP-8/TIMP-1 and MMP-9/TIMP-1 ratios with obesity-related biomarkers in apparently healthy adolescent boys.
METHODS
We measured MMP and TIMP concentrations in plasma samples using the enzyme-linked immunosorbent assay and analyzed their associations with obesity-related biomarkers, such as liver enzymes and lipid profiles, in a sample of 91 Korean boys aged 13-14 years who participated in a general health check-up.
RESULTS
The mean age of the boys was 13.8+/-0.3 years; 72 boys were normal weight and 19 were overweight/obese. The Pearson correlation coefficients revealed a significant correlation between MMP-8 and aspartate aminotransferase (r=0.217, P=0.039) and alanine aminotransferase (r=0.250, P=0.017) and between TIMP-1 and aspartate aminotransferase (r=0.267, P=0.011). In a multivariate linear regression analysis, serum alanine aminotransferase was positively associated with the MMP-8 level. There were no significant differences in the MMP-8, MMP-9, and TIMP-1 levels or MMP-8/TIMP-1 and MMP-9/TIMP-1 ratios between control and overweight/obese subjects.
CONCLUSION
We found a significant association between the MMP-8 level and alanine aminotransferase in the apparently healthy adolescent boys. These findings indicate that there may be a pathophysiological mechanism underlying the relationship between MMP-8 and liver enzymes in young adolescents.
Keyword
MeSH Terms
-
Adolescent*
Adult
Alanine Transaminase
Aspartate Aminotransferases
Atherosclerosis
Biomarkers*
Enzyme-Linked Immunosorbent Assay
Humans
Linear Models
Liver
Matrix Metalloproteinases
Overweight
Plasma
Risk Factors
Tissue Inhibitor of Metalloproteinase-1*
Alanine Transaminase
Aspartate Aminotransferases
Matrix Metalloproteinases
Tissue Inhibitor of Metalloproteinase-1
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- MMP-2 and MMP-9 Expressions in Breast Carcinomas and Relationship with Major Prognostic Factors
- Expression of Matrix Metalloproteinase-2 (MMP-2) and Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) in Pancreatic Ductal Adenocarcinoma
- Expression of MMP-2, MT1-MMP, and TIMP-2 mRNA in Breast Carcinomas
- Expression of Matrix Metalloproteinase (MMP)-2, MMP-9, Tissue Inhibitor of Metalloproteinase (TIMP)-1 and TIMP-2 in Adenocarcinomas of The Gallbladder
- Regulation of Matrix Metalloproteinase 2 Expression by an Adenosine A1 Agonist in Trabecular Meshwork Cells
