Korean J Pediatr.  2014 May;57(5):217-221. 10.3345/kjp.2014.57.5.217.

Cardiovascular risk factors of early atherosclerosis in school-aged children after Kawasaki disease

• Cho HJ
• Yang SI
• Kim KH
• Kim JN
• Kil HR

• KMID: 2284119
• DOI: http://doi.org/10.3345/kjp.2014.57.5.217

Abstract

PURPOSE
The aim of this study was to determine whether school-aged children with Kawasaki disease (KD) have an increased risk for early atherosclerosis.
METHODS
The study included 98 children. The children were divided into the following groups: group A (n=19), KD with coronary arterial lesions that persisted or regressed; group B (n=49), KD without coronary arterial lesions; and group C (n=30), healthy children. Anthropometric variables and the levels of biochemical markers, including total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A, apolipoprotein B, homocysteine, high-sensitivity C-reactive protein (hs-CRP), and brachial artery stiffness using pulse wave velocity were compared among the three groups.
RESULTS
There were no significant differences in blood pressure and body index among the three groups. Additionally, there was no sex-specific difference. Moreover, the levels of triglyceride, HDL-C, apolipoprotein A, and hs-CRP did not differ among the three groups. However, the levels of total cholesterol (P=0.018), LDL-C (P=0.0003), and apolipoprotein B (P=0.029) were significantly higher in group A than in group C. Further, the level of homocysteine and the aortic pulse wave velocity were significantly higher in groups A and B than in group C (P=0.0001).
CONCLUSION
School-aged children after KD have high lipid profiles and arterial stiffness indicating an increased risk for early atherosclerosis.

Keyword

Risk factors of cardiovascular diseases; Atherosclerosis; Mucocutaneous lymph node syndrome

MeSH Terms

Apolipoproteins
Atherosclerosis*
Biomarkers
Blood Pressure
Brachial Artery
C-Reactive Protein
Child*
Cholesterol
Homocysteine
Humans
Lipoproteins
Mucocutaneous Lymph Node Syndrome*
Pulse Wave Analysis
Risk Factors*
Triglycerides
Vascular Stiffness
Apolipoproteins
C-Reactive Protein
Cholesterol
Homocysteine
Lipoproteins