Cardiovasc Prev Pharmacother.  2019 Jul;1(1):3-9. 10.36011/cpp.2019.1.e2.

Asian Cohort Studies on Cardiovascular Risk Factors in Childhood

• Jung SJ
• Kim HC
• Suh I

• KMID: 2536958
• DOI: http://doi.org/10.36011/cpp.2019.1.e2

Abstract

Long-term cohort studies have shown that cardiovascular risk factors measured during childhood were associated with levels of adult cardiovascular risk factors and also with the lifetime risk of cardiovascular disease (CVD). However, most of the epidemiologic evidence was from Western studies and relatively small in the Asian population. From the literature, we identified and reviewed 8 Asian cohort studies focusing on cardiovascular risk factors among children. The Asian cohort studies have confirmed that childhood risk factors can predict later levels of adult risk factors. Besides, it has been shown that childhood risk factors are associated with intermediate phenotypes, such as metabolic disturbance and degenerative vascular changes, in adulthood. These findings reaffirmed the importance of screening and managing cardiovascular risk factors from early life in Asia. However, there is little evidence on CVD incidence and mortality because there is no Asian cohort study, which observed from childhood until middle-aged or old ages. Longer follow-up data are required to measure the impact of childhood cardiovascular risk factors, especially since obesity and other cardiovascular risk factors are increasing in Asian children and adolescents.

Keyword

Child; Adolescent; Cardiovascular disease; Asia

Reference

1. Rodrigues AN, Abreu GR, Resende RS, Goncalves WL, Gouvea SA. Cardiovascular risk factor investigation: a pediatric issue. Int J Gen Med. 2013; 6:57–66.

2. McGill HC Jr, McMahan CA. Determinants of atherosclerosis in the young. Pathobiological determinants of atherosclerosis in youth (PDAY) research group. Am J Cardiol. 1998; 82:30T–36T.

3. Berenson GS, Srinivasan SR, Bao W, Newman WP 3rd, Tracy RE, Wattigney WA. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med. 1998; 338:1650–6.

4. McGill HC Jr, McMahan CA, Zieske AW, Tracy RE, Malcom GT, Herderick EE, Strong JP. Association of coronary heart disease risk factors with microscopic qualities of coronary atherosclerosis in youth. Circulation. 2000; 102:374–9.

5. McMahan CA, Gidding SS, Malcom GT, Tracy RE, Strong JP, McGill HC Jr; Pathobiological Determinants of Atherosclerosis in Youth Research Group. Pathobiological determinants of atherosclerosis in youth risk scores are associated with early and advanced atherosclerosis. Pediatrics. 2006; 118:1447–55.

6. Lauer RM, Connor WE, Leaverton PE, Reiter MA, Clarke WR. Coronary heart disease risk factors in school children: the Muscatine study. J Pediatr. 1975; 86:697–706.

7. Berenson GS. Bogalusa Heart Study: a long-term community study of a rural biracial (black/white) population. Am J Med Sci. 2001; 322:267–74.

8. Raitakari OT, Juonala M, Rönnemaa T, Keltikangas-Järvinen L, Räsänen L, Pietikäinen M, Hutri-Kähönen N, Taittonen L, Jokinen E, Marniemi J, Jula A, Telama R, Kähönen M, Lehtimäki T, Akerblom HK, Viikari JS. Cohort profile: the cardiovascular risk in Young Finns Study. Int J Epidemiol. 2008; 37:1220–6.

9. Holmen TL, Bratberg G, Krokstad S, Langhammer A, Hveem K, Midthjell K, Heggland J, Holmen J. Cohort profile of the Young-HUNT Study, Norway: a population-based study of adolescents. Int J Epidemiol. 2014; 43:536–44.

10. Wijnstok NJ, Hoekstra T, van Mechelen W, Kemper HC, Twisk JW. Cohort profile: the Amsterdam Growth and Health Longitudinal Study. Int J Epidemiol. 2013; 42:422–9.

11. L'Abée C, Sauer PJ, Damen M, Rake JP, Cats H, Stolk RP. Cohort profile: the GECKO Drenthe study, overweight programming during early childhood. Int J Epidemiol. 2008; 37:486–9.

12. Hallal PC, Bertoldi AD, Domingues MR, da Silveira MF, Demarco FF, da Silva IC, Barros FC, Victora CG, Bassani DG. Cohort profile: the 2015 Pelotas (Brazil) birth cohort study. Int J Epidemiol. 2018; 47:1048–1048h.

13. Carsley S, Borkhoff CM, Maguire JL, Birken CS, Khovratovich M, McCrindle B, Macarthur C, Parkin PC; TARGet Kids! Collaboration. Cohort profile: the Applied Research Group for Kids (TARGet Kids!). Int J Epidemiol. 2015; 44:776–88.

14. Lambert M, Van Hulst A, O'Loughlin J, Tremblay A, Barnett TA, Charron H, Drapeau V, Dubois J, GrayDonald K, Henderson M, Lagacé G, Low NC, Mark S, Mathieu MÈ, Maximova K, McGrath JJ, Nicolau B, Pelletier C, Poirier P, Sabiston C, Paradis G. Cohort profile: the Quebec adipose and lifestyle investigation in youth cohort. Int J Epidemiol. 2012; 41:1533–44.

15. Pausova Z, Paus T, Abrahamowicz M, Bernard M, Gaudet D, Leonard G, Peron M, Pike GB, Richer L, Séguin JR, Veillette S. Cohort profile: the Saguenay Youth Study (SYS). Int J Epidemiol. 2017; 46:e19.

16. Ramachandran A, Snehalatha C. Rising burden of obesity in Asia. J Obes. 2010; 2010:868573.

17. Prasad DS, Kabir Z, Dash AK, Das BC. Childhood cardiovascular risk factors in South Asians: a cause of concern for adult cardiovascular disease epidemic. Ann Pediatr Cardiol. 2011; 4:166–71.

18. Ward JL, Harrison K, Viner RM, Costello A, Heys M. Adolescent cohorts assessing growth, cardiovascular and cognitive outcomes in low and middle-income countries. PLoS One. 2018; 13:e0190443.

19. Lee MH, Kang DR, Kim HC, Ahn SV, Khaw KT, Suh I. A 24-year follow-up study of blood pressure tracking from childhood to adulthood in Korea: the Kangwha Study. Yonsei Med J. 2014; 55:360–6.

20. Antonisamy B, Raghupathy P, Christopher S, Richard J, Rao PS, Barker DJ, Fall CH. Cohort profile: the 1969-73 Vellore birth cohort study in South India. Int J Epidemiol. 2009; 38:663–9.

21. Kinra S, Radha Krishna KV, Kuper H, Rameshwar Sarma KV, Prabhakaran P, Gupta V, Walia GK, Bhogadi S, Kulkarni B, Kumar A, Aggarwal A, Gupta R, Prabhakaran D, Reddy KS, Smith GD, Ben-Shlomo Y, Ebrahim S. Cohort profile: Andhra Pradesh Children and Parents Study (APCAPS). Int J Epidemiol. 2014; 43:1417–24.

22. Tan F, Okamoto M, Suyama A, Miyamoto T. Tracking of cardiovascular risk factors and a cohort study on hyperlipidemia in rural schoolchildren in Japan. J Epidemiol. 2000; 10:255–61.

23. Krishnaveni GV, Veena SR, Hill JC, Karat SC, Fall CH. Cohort profile: Mysore Parthenon birth cohort. Int J Epidemiol. 2015; 44:28–36.

24. Li S, Liu R, Arguelles L, Wang G, Zhang J, Shen X, Wang X. Adiposity trajectory and its associations with plasma adipokine levels in children and adolescents-a prospective cohort study. Obesity (Silver Spring). 2016; 24:408–16.

25. Trang NH, Hong TK, Dibley MJ. Cohort profile: Ho Chi Minh City Youth Cohort--changes in diet, physical activity, sedentary behaviour and relationship with overweight/obesity in adolescents. BMJ Open. 2012; 2:e000362.

26. Hur YI, Park H, Kang JH, Lee HA, Song HJ, Lee HJ, Kim OH. Associations between sugar intake from different food sources and adiposity or cardio-metabolic risk in childhood and adolescence: the Korean Child-Adolescent Cohort Study. Nutrients. 2015; 8:E20.

27. Lee PH, Macfarlane DJ, Lam TH, Stewart SM. Validity of the International Physical Activity Questionnaire Short Form (IPAQ-SF): a systematic review. Int J Behav Nutr Phys Act. 2011; 8:115.

28. Booth ML, Okely AD, Chey TN, Bauman A. The reliability and validity of the Adolescent Physical Activity Recall Questionnaire. Med Sci Sports Exerc. 2002; 34:1986–95.

29. Lee JH, Kim HC, Kang DR, Suh I. The 23-year tracking of blood lipids from adolescence to adulthood in Korea: the Kangwha Study. Lipids Health Dis. 2017; 16:221.

30. Yeom H, Kim HC, Lee JM, Jeon Y, Suh I. Triglyceride to high density lipoprotein cholesterol ratio among adolescents is associated with adult hypertension: the Kangwha Study. Lipids Health Dis. 2018; 17:212–212.

31. Kim HC. Indirect central blood pressure measurement may be a good indicator of long-term exposure to high blood pressure. In : The Pulse of Asia 2010; 2010 May 22-23; Shinagawa Intercity Hall. Tokyo. The Pulse of Asia; 2010 May.

32. Lee YJ, Nam CM, Kim HC, Hur NW, Suh I. The association between obesity indices in adolescence and carotid intima-media thickness in young adults: Kangwha Study. J Prev Med Public Health. 2008; 41:107–14.