Korean J Pediatr.  2009 Mar;52(3):370-375. 10.3345/kjp.2009.52.3.370.

Development of metabolic syndrome and its correlation with insulin resistance in adult patients with Turner syndrome

• Kim JH
• Kang MJ
• Shin CH
• Yang SW

• KMID: 2281117
• DOI: http://doi.org/10.3345/kjp.2009.52.3.370

Abstract

PURPOSE: The risk of metabolic syndrome (MS) and cardiovascular disease in Turner syndrome (TS) patients is high. We analyzed metabolic factors in adults with TS and evaluated the metabolic risk of insulin resistance.
METHODS
Forty-three adults with TS were enrolled. The frequency of MS and the values of the metabolic factors were analyzed. Patients were divided into insulin resistant and non-resistant groups according to values of homeostasis model assessment of insulin resistance (HOMA-IR). The correlations of HOMA-IR with metabolic parameters were analyzed.
RESULTS
The frequency of MS was 7% and those of each metabolic parameter were as follows: insulin resistance, 16.3%; central obesity, 15.4%; hypertriglyceridemia, 2.3%; low HDL cholesterol, 9.3%; hypertension, 36.8%. The insulin-resistant group had significantly higher values of body mass index (BMI), waist circumference (WC), fasting plasma glucose (FPG), HOMA-IR, and systolic blood pressure (SBP) than the non-resistant group (P<0.05). HOMA-IR showed a significantly positive correlation with BMI, WC, FPG, and SBP and showed a negative correlation with HDL cholesterol.
CONCLUSION
This study suggests that adults with TS have a high risk of metabolic syndrome, and insulin resistance is correlated with metabolic factors. Therefore, TS patients should have their metabolic parameters monitored regularly to minimize metabolic complications and prevent cardiovascular diseases.

Keyword

Turner syndrome; Adult; Metabolic syndrome; Cardiovascular disease; Insulin resistance

MeSH Terms

Adult
Blood Pressure
Body Mass Index
Cardiovascular Diseases
Cholesterol, HDL
Fasting
Glucose
Homeostasis
Humans
Hypertension
Hypertriglyceridemia
Insulin
Insulin Resistance
Obesity, Abdominal
Plasma
Turner Syndrome
Waist Circumference
Cholesterol, HDL
Glucose
Insulin