Korean J Pediatr.  2010 Aug;53(8):779-785. 10.3345/kjp.2010.53.8.779.

Multimodal neuroimaging in presurgical evaluation of childhood epilepsy

• Jung DE
• Lee JS

• KMID: 2280928
• DOI: http://doi.org/10.3345/kjp.2010.53.8.779

Abstract

In pre-surgical evaluation of pediatric epilepsy, the combined use of multiple imaging modalities for precise localization of the epileptogenic focus is a worthwhile endeavor. Advanced neuroimaging by high field Magnetic resonance imaging (MRI), diffusion tensor images, and MR spectroscopy have the potential to identify subtle lesions. 18F-FDG positron emission tomography and single photon emission tomography provide visualization of metabolic alterations of the brain in the ictal and interictal states. These techniques may have localizing value for patients which exhibit normal MRI scans. Functional MRI is helpful for non-invasively identifying areas of eloquent cortex. These advances are improving our ability to noninvasively detect epileptogenic foci which have gone undetected in the past and whose accurate localization is crucial for a favorable outcome following surgical resection.

Keyword

Multimodal neuroimaging; Childhood epilepsy; Surgery

MeSH Terms

Brain
Diffusion
Epilepsy
Fluorodeoxyglucose F18
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Neuroimaging
Positron-Emission Tomography
Fluorodeoxyglucose F18