Korean J Perinatol.  2003 Sep;14(3):305-311.

A Case of False Positive Amniotic Fluid Acetylcholinestserase in One Fetus of Twin Pregnancy conceived by Intracytoplasmic Sperm Injection and Zygote Intrafallopian Tube Transfer

• Eun MN
• Kim HC
• Shin SJ
• Cha SH
• Kim NK
• Kim JY
• Jung SG
• Kang SH
• Kim SJ
• Jung EH
• Lee KW

Abstract

Maternal serum alpha-fetoprotein(MSAFP) has been a world wide screening test for open neural the tube defect. But elevation of MSAFP is related to not only neural tube defect, but also incorrect gestational age, congenital anomalies such as congenital nephrosis, esophageal and intestinal obstruction, low birth weight, oligohydroamnios, fetal death and chromosomal anomalies. If MSAFP is elevated, gestational age, congenital anomalies such as neural tube defect, multiple pregnancy and fetal death must be evaluated by ultrasound. When the ultrasound is nondiagnostic, amniotic fluid AFP(AFAFP) levels are measured and if AFAFP is elevated, presence or absence of aetylchoineststarase(AChE) is determined to rule out the false positive of amniotic AFP. Amniotic AChE test yielded detection rate of open spina bifida of 99%, 98% for anecephaly and a false-positive rate of 0.34%. We report a case with elevated AFAFP and positive amniotic AChE result in one fetus of the twin pregnancy conceived by ICSI and ZIFT, but in which targeted ultrasound findings were normal, maintained the pregnancy to term and normal twin was delivered by elective cesarean section.

Keyword

Neural tube defect; Acetylcholinesterase; Alpha-fetoprotein

MeSH Terms

Acetylcholinesterase
alpha-Fetoproteins
Amniotic Fluid*
Cesarean Section
Female
Fetal Death
Fetus*
Gestational Age
Humans
Infant, Low Birth Weight
Infant, Newborn
Intestinal Obstruction
Mass Screening
Nephrosis
Neural Tube Defects
Pregnancy
Pregnancy, Multiple
Pregnancy, Twin*
Sperm Injections, Intracytoplasmic*
Spina Bifida Cystica
Ultrasonography
Zygote Intrafallopian Transfer
Zygote*
Acetylcholinesterase
alpha-Fetoproteins