Korean J Pediatr.  2007 Nov;50(11):1104-1109. 10.3345/kjp.2007.50.11.1104.

The impact of early detection through school urinary screening tests of membranoproliferative glomerulonephritis type

• Chung SH
• Park SS
• Kim SD
• Cho BS

• KMID: 2279370
• DOI: http://doi.org/10.3345/kjp.2007.50.11.1104

Abstract

PURPOSE: Since 1998, school urinary screening tests have been performed on Korean school children. We could detect and treat so many asymptomatic chronic renal disease in early stage. We investigated the efficacy of school urinary screening tests from children with membranoproliferative glomerulonephritis (MPGN) type I.
METHODS
We analyzed the characteristics and prognosis of 18 patients with MPGN type I who admitted after 1996 and received steroid therapy with or without cyclosporine. These patients were divided into two groups. Group A (asymptomatic patients detected by school urinary screening tests) consisted of 7 patients; Group S (symptomatic patients) consisted 11 patients.
RESULTS
Mean follow-up duration was 6.3 years (from 2 to 11 years). Urinary protein excretion was 1.1 g/day in group A and 6.6 g/day in group S. 24 hour creatinine clearance (mL/min/1.73m2) was 134.3 in group A and 82.3 in group S. No patients in group A had renal insufficiency, but three patients in group S had renal insufficiency and one patient required peritoneal dialysis.
CONCLUSION
Early detection by school urinary screening tests improves prognosis of MPGN type I.

Keyword

School urinary screening tests; Membranoproliferative glomerulonephritis; 24 hour creatinine clearance; Renal insufficiency; Steroid therapy

MeSH Terms

Child
Creatinine
Cyclosporine
Follow-Up Studies
Glomerulonephritis, Membranoproliferative*
Humans
Mass Screening*
Peritoneal Dialysis
Prognosis
Renal Insufficiency
Renal Insufficiency, Chronic
Creatinine
Cyclosporine