Korean J Pediatr.  2006 Sep;49(9):959-965. 10.3345/kjp.2006.49.9.959.

Effect of prophylactic indomethacin in extremely low birth weight infants

• Lee BL
• Kim SJ
• Koo SH
• Jeon GW
• Chang YS
• Park WS

• KMID: 2278529
• DOI: http://doi.org/10.3345/kjp.2006.49.9.959

Abstract

PURPOSE: The purpose of this study was to investigate the effect of prophylactic indomethacin on reduction of patent ductus arteriosus(PDA) and intraventricular hemorrhage(IVH) in extremely low birth weight infants(ELBWI).
METHODS
Retrospective review of 84 ELBWI who were admitted to our neonatal intensive care unit from June 2004 to April 2006 was performed. Patients were divided into prophylactic group(n=28) and control group(n=56), where prophylactic indomethacin were given within 6 hours after birth. Clinical outcomes were compared between these groups.
RESULTS
There were no significant differences in gestational age, birth weight, incidence of hemodynamically significant PDA and severe IVH, and mortality between prophylactic group and control group. However, there were more frequent indications for therapeutic indomethacin, higher incidence of intestinal perforation, and longer time to achieve full enteral feeding in prophylactic group than control group. The incidence of other adverse events attributed to indomethacin prophylaxis did not differ between two groups.
CONCLUSIONS
Prophylactic indomethacin may not prevent hemodynamically significant PDA and severe IVH in ELBWI. On the contrary, it may be associated with increased risk of adverse events. Further efforts should be investigated to decrease PDA and severe IVH in ELBWI.

Keyword

Indomethacin; Intraventricular hemorrhage; Patent ductus arteriosus; Extremly low birth weight infant

MeSH Terms

Birth Weight
Ductus Arteriosus, Patent
Enteral Nutrition
Gestational Age
Humans
Incidence
Indomethacin*
Infant*
Infant, Low Birth Weight*
Infant, Newborn
Intensive Care, Neonatal
Intestinal Perforation
Mortality
Parturition
Retrospective Studies
Indomethacin