Neonatal Med.  2013 Feb;20(1):67-74. 10.5385/nm.2013.20.1.67.

Oral Ibuprofen versus Intravenous Indomethacin for the Treatment of Patent Ductus Arteriosus in Very Low Birth Weight Infants

• Lee J
• Choi M
• Shim GH
• Song YH
• Chey MJ

• KMID: 2052457
• DOI: http://doi.org/10.5385/nm.2013.20.1.67

Abstract

PURPOSE
Ibuprofen and indomethacin has been used in treatment of patent ductus arteriosus (PDA) in Korea. But, there were few reports about oral ibuprofen for the treatment of PDA. We aimed to evaluate the efficacy and safety of oral ibuprofen versus intravenous indomethacin for the treatment of PDA in very low birth weight (VLBW) infants.
METHODS
A retrospective study of VLBW infants treated with oral ibuprofen or intravenous indomethacin for symptomatic PDA at Inje University Sanggye Paik Hospital between February 2002 and April 2012 was performed.
RESULTS
We identified 43 infants that received oral ibuprofen and 9 infants that received intravenous indomethacin. There were no significant differences in the efficacy and safety between oral ibuprofen group and intravenous indomethacin group. There was no significant difference between the use of oral ibuprofen before 48 hours after birth and after 48 hours the efficacy and safety.
CONCLUSION
In our study, oral ibuprofen appears to be as effective as intravenous indomethacin for the treatment of PDA in VLBW infants with similar complication rates.

Keyword

Ibuprofen; Indomethacin; Patent ductus arteriosus; Very low birth weight infants

MeSH Terms

Ductus Arteriosus, Patent
Humans
Ibuprofen
Indomethacin
Infant
Infant, Very Low Birth Weight
Korea
Parturition
Retrospective Studies
Ibuprofen
Indomethacin