Korean J Pathol.
2010 Apr;44(2):199-203.
A Case of Paraduodenal Pancreatitis and Immunohistochemical Analysis
- Affiliations
-
- 1Department of Pathology, Samsung Medical Center, Sungkyunkwan University College of Medicine, Seoul, Korea.
- 2Department of Pathology, Kangdong Sacred-Heart Hospital, Hallym University College of Medicine, Seoul, Korea. esnam2003@yahoo.co.kr
- 3Department of Surgery, Kangdong Sacred-Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
Abstract
- Paraduodenal pancreatitis (PP) is a rare, distinct form of chronic pancreatitis, and it is related to alcohol abuse in middle-aged men. A 36-year-old man with a history of chronic recurrent pancreatitis for 4 years and alcohol abuse for 15 years presented with abdominal pain. Computed tomography revealed a multilocular cystic mass 3.2 x 3 x 3 cm in size and it was located within the muscular layer of the duodenal wall. The cysts were lined by a single layer of eosinophilic cuboidal epithelial cells that stained positively for mucin (MUC)1, MUC6, cytokeratin (CK)7 and CK19 and they stained negatively for MUC2, MUC5AC and CK5/6. Mild, chronic inflammatory reaction around the cystic wall, Brunner's gland hyperplasia and several clusters of heterotopic pancreatic tissue were noted. We report here on a case of PP and we demonstrated that the pancreatitis was of pancreatic ductal cell origin according to the MUC and CK expression patterns we observed on the immunohistochemical analysis.
