Korean J Otorhinolaryngol-Head Neck Surg.
2009 Sep;52(9):724-729. 10.3342/kjorl-hns.2009.52.9.724.
Changes in the Regional Cerebral Blood Flow in Postlingual Deaf Patients Measured by ECD-SPECT: Preliminary Study
- Affiliations
-
- 1Department of Otolaryngology-HNS, The Catholic University of Korea College of Medicine, Seoul, Korea. snparkmd@catholic.ac.kr
- 2Department of Neurology, The Catholic University of Korea College of Medicine, Seoul, Korea.
- 3Department of Nuclear Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
- KMID: 2277093
- DOI: http://doi.org/10.3342/kjorl-hns.2009.52.9.724
Abstract
-
BACKGROUND AND OBJECTIVES: Cochlear implantation improves hearing ability in adults with profound deafness. Using non-invasive functional brain imaging methods, it is now possible to assess regional blood flow and activity of auditory cortex which might be correlated to the outcome of cochlear implantation. The aim of this study was to measure the regional cerebral blood flow in patients with postlingual deafness utilizing controls in a variety of methods.
SUBJECTS AND METHOD
Six postlingual deaf adults who were planned to undertake cochlear implantation and 12 normal controls were examined with technetium-99m-labeled ethyl cysteinate dimer single-photon emission computed tomography (99mTc-ECD-SPECT). Images of the regional cerebral blood flow were processed by statistical parametric mapping and analyzed by unpaired t-test.
RESULTS
The analysis of the SPECT images of the 6 deaf patients showed decreased cerebral blood flow in both superior, middle temporal and inferior prefrontal lobes compared with controls (p<0.001). Also this decreased auditory cortical blood flow was greater in left hemisphere in all patients.
CONCLUSION
The degree of remaining activity of auditory cortex and the lateralization of the dominant auditory hemisphere, which may influence on the outcome of cochlear implantation, could be measured by ECD-SPECT.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Regional Cerebral Blood Flow Changes in Alzheimer's Disease Patients Treated with Cholinesterase Inhibitors: A Preliminary Study using 99mTC-ECD SPECT
- Diagnosis of Cerebrovascular Disease Using 99mTc-HMPAO SPECT
- Resting and Acetazolamide-Challenged Technetium 99m-ECD SPECT in Transient Global Amnesia
- Alterations of Regional Cerebral Blood Flow in Major Depressive Disorder
- Regional Cerebral Blood Flow Changes in Traumatic Carotid Cavernous Fistula During Trapping Procedure: Case Study, Preliminary Report
