Korean J Otolaryngol-Head Neck Surg.  2005 Aug;48(8):1008-1013.

Comparison of Midazolam with and without Nalbuphine for Intravenous Sedation in Nasal Surgery

• Jeon EJ
• Park YS
• Lee SK
• Lee SE
• Jang Y

Abstract

BACKGROUND AND OBJECTIVES
Effective and safe premedication in nasal surgery is very important in nasal surgery under local anesthesia. We investigated the effects of preoperative administration of midazolam only and midazolam combined with nalbuphine HCl for nasal surgery under local anesthesia. SUBJECTS AND METHOD: A total of 30 patients presenting for nasal surgery under local anesthesia were randomly assigned. Patients in the midazolam group (n=15) received single administration of midazolam and subjects in the nalbuphine group (n=15) were injected nalbuphine in addition to midazolam. Cardiovascular and respiratory status were monitored continuously. Questionnaires were given to the operator and the patients, and the scores were compared statistically. RESULTS: Operator's assessment indicated better pain control gain in the nalbuphine group. The other parameters in the operator's assessment and the patient's assessments were not statistically significant between the two groups. No adverse cardiovascular and respiratory side effects were noted, but pruritus was observed more frequently in the nalbuphine group. CONCLUSION: Better pain control gain was indicated only by the surgeon for the nalbuphine group, but there was no additional advantage in other parameters of combining nalbuphine with midazolam. We concluded that a single preoperative administration of midazolam would be effective enough and serve as a safe method for simple nasal surgery.

Keyword

Premedication; Midazolam; Nalbuphine

MeSH Terms

Anesthesia, Local
Humans
Midazolam*
Nalbuphine*
Nasal Surgical Procedures*
Premedication
Pruritus
Surveys and Questionnaires
Midazolam
Nalbuphine