Korean J Otolaryngol-Head Neck Surg.  2004 Sep;47(9):923-927.

A Case of MALT Lymphoma Showing Mikulicz Syndrome

• Ryu JY
• Choi HY
• Shin C
• Lee DH

Abstract

Since Mikulicz's description of symptomless hypertrophy of the salivary gland and lacrimal gland, the term, Mikulicz syndrome, has been used to describe enlargement of the salivary gland with or without lacrimal gland involvement occurring in leukemia, lymphosarcoma, sarcoidosis, tuberculosis syphilis, etc. However, there are still a tremendous amount of confusion in the application of the term, Mikulicz syndrome. In Korea, there has been no reported case of Mikulicz syndrome to date. Internationally, it is also extremely rare to spot a reported case of the disease originating primarily from submandibular glands. We would like to report a case in which a 56 year old female patient was reported to have the disease ; she was diagnosed initially as benign lymphoepithelial lesion (BLL) by submandibular biopsy, but later confirmed by lacrimal gland biopsy to have mucosa associated lymphoid tissue (MALT).

Keyword

Mucosa associated lymphoid tissue lymphoma; Salivary gland; Lacrimal gland

MeSH Terms

Biopsy
Female
Humans
Hypertrophy
Korea
Lacrimal Apparatus
Leukemia
Lymphoid Tissue
Lymphoma, B-Cell, Marginal Zone*
Lymphoma, Non-Hodgkin
Middle Aged
Mucous Membrane
Salivary Glands
Sarcoidosis
Submandibular Gland
Syphilis
Tuberculosis