Korean J Otolaryngol-Head Neck Surg.
2002 Aug;45(8):791-795.
Prognostic Significance of Expression of Glutathione S-Transferase-pi and Multidrug Resistance-Associated Protein in Nasopharyngeal Carcinoma
- Affiliations
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- 1Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School, Gwangju, Korea. cjscyy@chonnam.ac.kr
Abstract
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BACKGROUND AND OBJECTIVES: For the treatment of nasopharyngeal carcinoma (NPC), radiation therapy is a primary option. Because of distant metastasis and the high incidence of a locoregional failure following radiotherapy, the combined treatment modality with chemotherapy is applied, although resistance to chemotherapy makes chemotherapy less effective. The Cisplatin-based chemotherapy has been widely used in the field of nasopharyngeal cancer. The Cisplatin resistance is known to be caused by the multidrug resistance-associated protein (MRP), which is one of the drug-export pumps and the glutathione S-transferase (GST)-pi which catalyzes the conjugation of the GSH (glutathione) and the cisplatin. The aim of this study is to determine the predictive value of GST-pi and MRP upon the response to cisplatin in nasopharyngeal carcinoma.
SUBJECTS AND METHOD
We analyzed tumor tissues from 49 cases of paraffin block specimens which were diagnosed with NPC and treated at Chonnam National University Hospital. The immunohistochemical study for the GST-pi and the MRP was performed with paraffin block specimens of nasopharyngeal cancers.
RESULTS
In the GST-pi, the relationship between the early stage (64.3%) and the advanced stage (91.4%) was statistically significant (p=0.020). The expression of the GST-pi and the MRP had no relationship with the clinical factor, the response to chemotherpy and the survival rate.
CONCLUSION
Because the expression of the GST-pi and the MRP in the nasopharyngeal carcinoma could not predict the response to chemotherapy. So the efforts to find the predictive value of the chemotherapy are needed.
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