Chonnam Med J.
2002 Sep;38(3):185-189.
Telomere Length Shortening in Malignant Patients Undergoing Chemotherapy
- Affiliations
-
- 1Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. hjoonk@chonnam.ac.kr
- 2Genome Research Center for Hematopoietic Diseases, Chonnam National University Hospital, Gwangju, Korea.
Abstract
- We investigated telomere length changes in patients with non-Hodgkins lymphoma (NHL) receiving conventional-dose chemotherapy. Using Southern blot analysis, telomere length was measured in peripheral blood mononuclear cells from five NHL patients at diagnosis, 15 NHL patients after chemotherapy, and 39 healthy controls. Telomere length in patients with NHL was significantly shorter at diagnosis than that of age-matched putative normal controls. Telomeres length in NHL patients were significantly shorter at diagnosis than that of age-matched putative normal controls. Mean telomere length was shorter after chemotherapy than before chemotherapy, and was shorter after chemotherapy than age-matched putative controls. There was no correlation between the extent of telomere shortening and time elapsed after chemotherapy. These findings suggest that in NHL patients, hematopoietic stem cells lose telomere length during the recovery period after conventional-dose chemotherapy.
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