- Autophagy, Cellular Aging and Age-related Human Diseases
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Cheon SY, Kim H, Rubinsztein DC, Lee JE
- KMID: 2468882
- Exp Neurobiol.
- 2019 Dec;28(6):643-657.
- doi: 10.5607/en.2019.28.6.643
Macroautophagy/autophagy is a conserved degradation system that engulfs intracytoplasmic contents, including aggregated proteins and organelles, which is crucial for cellular homeostasis. During aging, cellular factors suggested as the cause of... -
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- Telomere Biology in Mood Disorders: An Updated, Comprehensive Review of the Literature
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Muneer A, Minhas FA
- KMID: 2457398
- Clin Psychopharmacol Neurosci.
- 2019 Aug;17(3):343-363.
- doi: 10.9758/cpn.2019.17.3.343
Major psychiatric disorders are linked to early mortality and patients afflicted with these ailments demonstrate an increased risk of developing physical diseases that are characteristically seen in the elderly. Psychiatric... -
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- Leukocyte Telomere Length Reflects Prenatal Stress Exposure, But Does Not Predict Atopic Dermatitis Development at 1 Year
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Suh DI, Kang MJ, Park YM, Lee JK, Lee SY, Sheen YH, Kim KW, Ahn K, Won HS, Lee MY, Choi SJ, Kwon JY, Park HJ, Jun JK, Hong SJ, Koh YY
- KMID: 2442047
- Allergy Asthma Immunol Res.
- 2019 May;11(3):357-366.
- doi: 10.4168/aair.2019.11.3.357
PURPOSE: Prenatal maternal stress affects offspring's atopic dermatitis (AD) development, which is thought to be mediated by the oxidative stress. We aimed to evaluate the difference in leukocyte telomere length... -
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- Relationship between Telomere Maintenance and Liver Disease
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Barnard A, Moch A, Saab S
- KMID: 2434385
- Gut Liver.
- 2019 Jan;13(1):11-15.
- doi: 10.5009/gnl18081
Previous studies have established a correlation between increasing chronological age and risk of cirrhosis. This pattern raised interest in the role of telomeres and the telomerase complex in the pathogenesis... -
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- Dysregulation of Telomere Lengths and Telomerase Activity in Myelodysplastic Syndrome
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Park HS, Choi J, See CJ, Kim JA, Park SN, Im K, Kim SM, Lee DS, Hwang SM
- KMID: 2369744
- Ann Lab Med.
- 2017 May;37(3):195-203.
- doi: 10.3343/alm.2017.37.3.195
BACKGROUND: Telomere shortening is thought to be involved in the pathophysiology of myeloid malignancies, but telomere lengths (TL) during interphase and metaphase in hematopoietic malignancies have not been analyzed. We... -
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- Amyloid-beta oligomers regulate the properties of human neural stem cells through GSK-3beta signaling
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Lee IS, Jung K, Kim IS, Park KI
- KMID: 2154279
- Exp Mol Med.
- 2013 Nov;45(11):e60.
Alzheimer's disease (AD) is the most common cause of age-related dementia. The neuropathological hallmarks of AD include extracellular deposition of amyloid-beta peptides and neurofibrillary tangles that lead to intracellular hyperphosphorylated... -
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- Chemoprevention of Gastrointestinal Cancer: The Reality and the Dream
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Chun KS, Kim EH, Lee S, Hahm KB
- KMID: 2135063
- Gut Liver.
- 2013 Mar;7(2):137-149.
Despite substantial progress in screening, early diagnosis, and the development of noninvasive technology, gastrointestinal (GI) cancer remains a major cause of cancer-associated mortality. Chemoprevention is thought to be a realistic... -
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- Genome-scale DNA methylation pattern profiling of human bone marrow mesenchymal stem cells in long-term culture
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Choi MR, In YH, Park J, Park T, Jung KH, Chai JC, Chung MK, Lee YS, Chai YG
- KMID: 1387361
- Exp Mol Med.
- 2012 Aug;44(8):503-512.
Human bone marrow mesenchymal stem cells (MSCs) expanded in vitro exhibit not only a tendency to lose their proliferative potential, homing ability and telomere length but also genetic or epigenetic... -
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- Kidneys with bad ends
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Suh D
- KMID: 2322081
- J Korean Soc Pediatr Nephrol.
- 2008 Apr;12(1):11-22.
Telomeres consist of tandem guanine-thymine(G-T) repeats in most eukaryotic chromosomes. Human telomeres are predominantly linear, double stranded DNA as they ended in 30-200 nucleotides(bases,b) 3'-overhangs. In DNA replication, removal of... -
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- Telomere Length Shortening in Malignant Patients Undergoing Chemotherapy
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Lee JJ, Nam CE, Cho SH, Chung IJ, Kim HJ
- KMID: 2274967
- Chonnam Med J.
- 2002 Sep;38(3):185-189.
We investigated telomere length changes in patients with non-Hodgkins lymphoma (NHL) receiving conventional-dose chemotherapy. Using Southern blot analysis, telomere length was measured in peripheral blood mononuclear cells from five NHL... -
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- Telomerase Activity and Expression of hTR and TERT in Human Soft Tissue Sarcomas
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Yoo J, Kang SJ, Kim BK
- KMID: 1972968
- Cancer Res Treat.
- 2002 Feb;34(1):46-51.
PURPOSE: Sarcomas have rarely been analyzed for telomerase, which is an RNA-dependent DNA polymerase to maintain telomeres and prevent telomere shortening. This study was undertaken to determine telomerase activity and... -
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- N-nitrosomorpholine Directed Preneoplastic Reprogramming of Nuclear Metabolism of Rat Hepatocytes
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Kim MC, Jeong JS, Choi YC, Jung GJ, Kim SS
- KMID: 2329193
- J Korean Cancer Assoc.
- 2000 Dec;32(6):1075-1083.
PURPOSE: An attempt was made to investigate N-nitrosomorpholine (NNM) induced carcinogenic processes in rat liver. MATERIALS AND METHODS: Rats were fed with NNM (200 mg/l) for 7 weeks, after then stopped.... -
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- Telomerase Activity and Expression of MIB-1 and bcl-2 in Human Chorionic Villi from Early and Term Normal Pregnancy
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Cho JS, Kang YS, Moon IG, Choi BC, Lee JP, Lee HT, Hong SR
- KMID: 1725734
- Korean J Pathol.
- 2000 Nov;34(11):927-933.
Telomerase is an enzyme that maintains telomeres and prevents telomere shortening, and may be linked with cellular proliferation or the aging process. The purpose was to examine telomerase activity in... -
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- Telomerase Activity in Breast Cancer and Benign Breast Disease of Korea
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Park WC, Seo YJ, Choi SH, You YK, Cho WI, Kim CS, Oh SC, Jung SS, Kim IC
- KMID: 2173664
- J Korean Breast Cancer Soc.
- 1999 Jun;2(1):51-56.
- doi: 10.4048/jkbcs.1999.2.1.51
BACKGROUND: Telomerase is an RNA-dependent DNA polymerase that compensates for the telomere shortening that occurs in its absence. Reactivation of telomerase is thought to be an important step in cellular... -
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- Different Phase of Telomere Shortening with Age in Peripheral Blood Mononuclear Cells
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Kang JS, Kook H, Yoon WS, Kim CJ, Hwang TJ
- KMID: 2072473
- Korean J Pediatr Hematol Oncol.
- 1999 Apr;6(1):31-38.
PURPOSE: Telomeres, special protein and tandem repeat DNA structure that cap the ends of linear eukaryotic chromosomes, are essential for chromosome structure and stability. Human telomeric DNA is known... -
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- Telomerase Activities in Ovarian Malignancies
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Song JH, Cho CH, Cha SD, Lee TS
- KMID: 2260913
- Korean J Obstet Gynecol.
- 1998 Apr;41(4):1029-1035.
Telomerase is a ribonucleoprotein that can add hexameric TTAGGG sequences to the end of chromosomes and thus stabilize telomeres. Telomeres are shortened by progression of cell division, a process known... -
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