- How Does Obesity and Physical Activity Affect Aging?: Focused on Telomere as a Biomarker of Aging
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Shin YA
- KMID: 2459821
- J Obes Metab Syndr.
- 2019 Jun;28(2):92-104.
- doi: 10.7570/jomes.2019.28.2.92
Obesity is known to continuously increase systemic inflammation and oxidative stress, leading to shorter telomere length. However, research regarding the correlation between physical activity, exercise, obesity, and telomere length is... -
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- Relationship between Telomere Maintenance and Liver Disease
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Barnard A, Moch A, Saab S
- KMID: 2434385
- Gut Liver.
- 2019 Jan;13(1):11-15.
- doi: 10.5009/gnl18081
Previous studies have established a correlation between increasing chronological age and risk of cirrhosis. This pattern raised interest in the role of telomeres and the telomerase complex in the pathogenesis... -
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- Telomere Length Shortening in Malignant Patients Undergoing Chemotherapy
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Lee JJ, Nam CE, Cho SH, Chung IJ, Kim HJ
- KMID: 2274967
- Chonnam Med J.
- 2002 Sep;38(3):185-189.
We investigated telomere length changes in patients with non-Hodgkins lymphoma (NHL) receiving conventional-dose chemotherapy. Using Southern blot analysis, telomere length was measured in peripheral blood mononuclear cells from five NHL... -
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- Telomere Length Changes in Colorectal Cancers and Polyps
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Kim HR, Kim YJ, Kim HJ, Kim SK, Lee JH
- KMID: 1101551
- J Korean Med Sci.
- 2002 Jun;17(3):360-365.
- doi: 10.3346/jkms.2002.17.3.360
Telomere Length Changes in Colorectal Cancers and Polyps Telomere shortening and telomerase activation occur frequently in cases of colorectal carcinoma. In this study, we correlated the clinicopathological parameters with the... -
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- Telomerase: Key to Mortal or Immortal Road
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Yang EY, Sung YH, Lee HW
- KMID: 1974515
- Immune Netw.
- 2002 Dec;2(4):183-188.
- doi: 10.4110/in.2002.2.4.183
Gradual attrition of telomere to a critical short length elicits successive cellular response of cellular senescence and crisis. Cancer cells evade this process by maintaining functional telomeres via one of... -
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- New Functions for Telomerase
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Hahn WC
- KMID: 1972865
- Cancer Res Treat.
- 2003 Dec;35(6):467-471.
Telomeres are nucleoprotein structures that compose the ends of eukaryotic chromosomes and that regulate chromosome integrity and cell proliferative lifespan. Stabilization of telomere length correlates with cell immortalization, and constitutive... -
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- Different Phase of Telomere Shortening with Age in Peripheral Blood Mononuclear Cells
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Kang JS, Kook H, Yoon WS, Kim CJ, Hwang TJ
- KMID: 2072473
- Korean J Pediatr Hematol Oncol.
- 1999 Apr;6(1):31-38.
PURPOSE: Telomeres, special protein and tandem repeat DNA structure that cap the ends of linear eukaryotic chromosomes, are essential for chromosome structure and stability. Human telomeric DNA is known... -
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- Mouse models for telomere and telomerase biology
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Cheong C, Hong KU, Lee HW
- KMID: 1094694
- Exp Mol Med.
- 2003 Jun;35(3):141-153.
Telomeres serve a critical role in maintenance of genomic stability in all eukaryotes, from yeast to human. The maintenance of telomeres is achieved by the telomerase complex, which is largely... -
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- Replication of the results of genome-wide and candidate gene association studies on telomere length in a Korean population
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Do SK, Yoo SS, Choi YY, Choi JE, Jeon HS, Lee WK, Lee SY, Lee J, Cha SI, Kim CH, Park JY
- KMID: 2381571
- Korean J Intern Med.
- 2015 Sep;30(5):719-726.
- doi: 10.3904/kjim.2015.30.5.719
BACKGROUND/AIMS: A number of genome-wide and candidate gene association studies have identified polymorphisms associated with telomere length in Caucasian populations. This study was conducted to determine the impacts of 17... -
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- Extracting Extra-Telomeric Phenotypes from Telomerase Mouse Models
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Sung YH, Ali M, Lee HW
- KMID: 1779879
- Yonsei Med J.
- 2014 Jan;55(1):1-8.
- doi: 10.3349/ymj.2014.55.1.1
Telomerase reverse transcriptase (TERT) is the protein component of telomerase and combined with an RNA molecule, telomerase RNA component, forms the telomerase enzyme responsible for telomere elongation. Telomerase is essential... -
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- Effect of Long-Term Hormone Therapy on Telomere Length in Postmenopausal Women
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Lee DC, Im JA, Kim JH, Lee HR, Shim JY
- KMID: 1716515
- Yonsei Med J.
- 2005 Aug;46(4):471-479.
- doi: 10.3349/ymj.2005.46.4.471
Telomeres undergo attrition with each cell division, and telomere length is associated with age-related diseases and mortality in the elderly. Estrogen can influence the attrition of telomeres by diverse mechanisms.... -
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- Associations of alcohol consumption and alcohol flush reaction with leukocyte telomere length in Korean adults
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Wang H, Kim H, Baik I
- KMID: 2385472
- Nutr Res Pract.
- 2017 Aug;11(4):334-339.
- doi: 10.4162/nrp.2017.11.4.334
BACKGROUND/OBJECTIVES: Telomere length is a useful biomarker for determining general aging status. Some studies have reported an association between alcohol consumption and telomere length in a general population; however, it... -
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- Telomere Biology in Mood Disorders: An Updated, Comprehensive Review of the Literature
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Muneer A, Minhas FA
- KMID: 2457398
- Clin Psychopharmacol Neurosci.
- 2019 Aug;17(3):343-363.
- doi: 10.9758/cpn.2019.17.3.343
Major psychiatric disorders are linked to early mortality and patients afflicted with these ailments demonstrate an increased risk of developing physical diseases that are characteristically seen in the elderly. Psychiatric... -
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- Kidneys with bad ends
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Suh D
- KMID: 2322081
- J Korean Soc Pediatr Nephrol.
- 2008 Apr;12(1):11-22.
Telomeres consist of tandem guanine-thymine(G-T) repeats in most eukaryotic chromosomes. Human telomeres are predominantly linear, double stranded DNA as they ended in 30-200 nucleotides(bases,b) 3'-overhangs. In DNA replication, removal of... -
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- Comparative binding of antitumor drugs to DNA containing the telomere repeat sequence
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Suh D, Oh YK, Ahn BC, Hur MW, Kim HJ, Lee MH, Joo HS, Auh CK
- KMID: 755203
- Exp Mol Med.
- 2002 Nov;34(5):326-331.
Telomeres are the ends of the linear chromosomes of eukaryotes and consist of tandem GT-rich repeats in telomere sequence i.e. 500-3000 repeats of 5'-TTAGGG-3' in human somatic cells, which are... -
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- Prognostic Value of TZAP Expression in Various Cancers: TCGA Data Analysis
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Park WJ, Heo YR, Lee JH
- KMID: 2437656
- Keimyung Med J.
- 2018 Jun;37(1):17-21.
- doi: 10.0000/kmj.2018.37.1.17
The zinc finger protein ZBTB48 is a telomere-associated factor and renamed it as telomeric zinc finger-associated protein (TZAP). It binds preferentially to long telomeres competing with TRF1 and TRF2. However,... -
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- TERT Polymorphism rs2853669 Influences on Lung Cancer Risk in the Korean Population
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Yoo SS, Do SK, Choi JE, Lee SY, Lee J, Cha SI, Kim CH, Park JY
- KMID: 2344174
- J Korean Med Sci.
- 2015 Oct;30(10):1423-1428.
- doi: 10.3346/jkms.2015.30.10.1423
Short telomeres are known as one of the risk factors for human cancers. The present study was conducted to evaluate the association between 6 polymorphisms, which were related with short... -
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- Walnut phenolic extracts reduce telomere length and telomerase activity in a colon cancer stem cell model
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Shin PK, Zoh Y, Choi J, Kim MS, Kim Y, Choi SW
- KMID: 2434077
- Nutr Res Pract.
- 2019 Feb;13(1):58-63.
- doi: 10.4162/nrp.2019.13.1.58
BACKGROUND/OBJECTIVES: Telomeres are located at the chromosomal ends and progressively shortened during each cell cycle. Telomerase, which is regulated by hTERT and c-MYC, maintains telomeric DNA sequences. Especially, telomerase is... -
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- Caveolin-1 is involved in high glucose accelerated human glomerular mesangial cell senescence
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Feng X, Gao W, Li Y
- KMID: 2411491
- Korean J Intern Med.
- 2017 Sep;32(5):883-889.
- doi: 10.3904/kjim.2015.254
BACKGROUND/AIMS:: We demonstrated the role of caveolin-1 involved in high glucose (HG)-induced glomerular mesangial cells (GMCs) senescence. METHODS:: HG was used to stimulate GMCs. The telomere lengths were analyzed by Southern... -
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- How Long Can We Live?
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Chung HY
- KMID: 1539424
- J Korean Geriatr Soc.
- 1999 Dec;3(4):1-10.
Potential maximum life span of humans is estimated around 115-120 years by Cutler. His estimate agrees with an earlier observation by Buffon who claimed that animals tended to live six... -
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