Chonnam Med J.  2012 Apr;48(1):1-6. 10.4068/cmj.2012.48.1.1.

Molecular Mechanisms Involved in Depotentiation and Their Relevance to Schizophrenia

• Sanderson

• KMID: 2274874
• DOI: http://doi.org/10.4068/cmj.2012.48.1.1

Abstract

Long-term potentiation (LTP) and long-term depression (LTD) of synaptic transmission are forms of synaptic plasticity that have been studied extensively and are thought to contribute to learning and memory. The reversal of LTP, known as depotentiation (DP) has received far less attention however, and its role in behavior is also far from clear. Recently, deficits in depotentiation have been observed in models of schizophrenia, suggesting that a greater understanding of this form of synaptic plasticity may help reveal the physiological alterations that underlie symptoms experienced by patients. This review therefore seeks to summarize the current state of knowledge on DP, and then put the deficits in DP in models of disease into this context.

Keyword

Neuronal plasticity; Long-term potentiation; Long-term synaptic depression; Schizophrenia

MeSH Terms

Depression
Humans
Learning
Long-Term Potentiation
Long-Term Synaptic Depression
Memory
Neuronal Plasticity
Plastics
Schizophrenia
Synaptic Transmission
Plastics