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Molecular Mechanisms Involved in Depotentiation and Their Relevance to Schizophrenia

Sanderson

Long-term potentiation (LTP) and long-term depression (LTD) of synaptic transmission are forms of synaptic plasticity that have been studied extensively and are thought to contribute to learning and memory. The...
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Long-term Synaptic Plasticity: Circuit Perturbation and Stabilization

Park JM, Jung SC, Eun SY

At central synapses, activity-dependent synaptic plasticity has a crucial role in information processing, storage, learning, and memory under both physiological and pathological conditions. One widely accepted model of learning mechanism...
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The Role of NMDA Receptor in Learning and Memory

Kim SH, Shin KH

  • KMID: 2317334
  • Sleep Med Psychophysiol.
  • 2000 Jun;7(1):10-17.
To investigate the neurobiological bases of learning and memory is one of the ambitious goals of modern neuroscience. The progress in this field of recent years has not only brought...
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Long-Term Potentiation of Excitatory Synaptic Strength in Spinothalamic Tract Neurons of the Rat Spinal Cord

Hur SW, Park JM

Spinal dorsal horn nociceptive neurons have been shown to undergo long-term synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD). Here, we focused on the spinothalamic tract (STT) neurons...
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Cortical Depression and Potentiation: Basic Mechanisms for Phantom Pain

Zhuo M

People experience the feeling of the missing body part long after it has been removed after amputation are known as phantom limb sensations. These sensations can be painful, sometimes becoming...
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The Role of PKMzeta in Drug Reward Memory

Song MJ, Kim JH

  • KMID: 2287495
  • Korean J Psychopharmacol.
  • 2012 Jul;23(3):83-87.
Drug addiction is a chronic brain disease with a high incidence of relapse. Environmental cues that previously and repeatedly associated with drugs of abuse easily evoke relapse to addicts even...
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Effect of Fluoxetine on the Induction of Long-term Potentiation in Rat Frontal Cortex

Kim HS, Kim HS, Hahn SJ, Kim MJ, Yoon SH, Jo YH, Kim MS, Rhie DJ

  • KMID: 1611484
  • Korean J Physiol Pharmacol.
  • 2004 Dec;8(6):295-300.
Serotonin (5-hydroxytroptamine, 5-HT) has been shown to affect the induction of long-term potentiation (LTP) in the cortex such as the hippocampus, the visual cortex and the prefrontal cortex. Fluoxetine, as...
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Reduction of long-term potentiation at Schaffer collateral-CA1 synapses in the rat hippocampus at the acute stage of vestibular compensation

Lee GW, Kim JH, Kim MS

Vestibular compensation is a recovery process from vestibular symptoms over time after unilateral loss of peripheral vestibular end organs. The aim of the present study was to observe time-dependent changes...
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Effects of Chronic and Acute Lithium Treatment on the Long-term Potentiation and Spatial Memory in Adult Rats

Yousef M, Kavraal Å, Artış AS, Süer C

OBJECTIVE: Although, accumulating evidence is delineating a neuroprotective and neurotrophic role for lithium (Li), inconsistent findings have also been reported in human studies especially. Moreover, the effects of Li infusion...
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Neurokinin and Its Receptors: Association with Learning and Memory

Kim MD, Lee CI

  • KMID: 2287030
  • Korean J Psychopharmacol.
  • 2007 Sep;18(5):280-287.
The neurokinin Substance P is widely distributed in the central nervous system and has been extensively studied in various functional aspects. Substance P has been reported to have memory-promoting, reinforcing,...
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REM Sleep and Memory

Yang CK

  • KMID: 2317258
  • Sleep Med Psychophysiol.
  • 1996 Jun;3(1):15-24.
After rapid eye movement(REM) sleep was idenified in 1953, a lively interest developed concerning a possible role of this kind of sleep in memory processes. The author reviewed studies relating...
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Changes in Synaptic Transmission and Long-term Potentiation Induction as a Possible Mechanism for Learning Disability in an Animal Model of Multiple Sclerosis

Mosayebi G, Soleyman M, khalili M, Mosleh M, Palizvan M

PURPOSE: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. It has been shown that memory deficits is common in patients with MS. Recent studies...
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Effects of Serotonin on the Induction of Long-term Depression in the Rat Visual Cortex

Jang HJ, Cho KH, Park SW, Kim MJ, Yoon SH, Rhie DJ

Long-term potentiation (LTP) and long-term depression (LTD) have both been studied as mechanisms of ocular dominance plasticity in the rat visual cortex. In a previous study, we suggested that a...
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Circadian Regulation by REV-ERBα Mediates Hippocampal E-LTP in a Time-dependent Manner

Choi JE, Kim S, Lee J, Kim K, Kaang BK

Circadian rhythms are driven by circadian oscillators, and these rhythms result in the biological phenomenon of 24-h oscillations. Previous studies suggest that learning and memory are affected by circadian rhythms....
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Developmental Switch of the Serotonergic Role in the Induction of Synaptic Long-term Potentiation in the Rat Visual Cortex

Park SW, Jang HJ, Cho KH, Kim MJ, Yoon SH, Rhie DJ

Synaptic long-term potentiation (LTP) and long-term depression (LTD) have been studied as mechanisms of ocular dominance plasticity in the rat visual cortex. Serotonin (5-hydroxytryptamine, 5-HT) inhibits the induction of LTP...
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Increases in Effective Cleft Glutamate Concentration During Expression of LTP

Jung SH, Choi S

  • KMID: 1615001
  • Korean J Physiol Pharmacol.
  • 2002 Apr;6(2):113-120.
Long-term potentiation (LTP) at hippocampal CA3-CA1 synapses is often associated with increases in quantal size, traditionally attributed to enhanced availability or efficacy of postsynaptic glutamate receptors. However, augmented quantal size...
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Enhancement of GluN2B Subunit-Containing NMDA Receptor Underlies Serotonergic Regulation of Long-Term Potentiation after Critical Period in the Rat Visual Cortex

Joo K, Rhie DJ, Jang HJ

Serotonin [5-hydroxytryptamine (5-HT)] regulates synaptic plasticity in the visual cortex. Although the effects of 5-HT on plasticity showed huge diversity depending on the ages of animals and species, it has...
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Phorbol 12-Myristate 13-Acetate Enhances Long-Term Potentiation in the Hippocampus through Activation of Protein Kinase Cdelta and epsilon

Kim EC, Lee MJ, Shin SY, Seol GH, Han SH, Yee J, Kim C, Min SS

Many intracellular proteins and signaling cascades contribute to the sensitivity of N-methyl-D-aspartate receptors (NMDARs). One such putative contributor is the serine/threonine kinase, protein kinase C (PKC). Activation of PKC by...
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A Functional Role for CREB as a Positive Regulator of Memory Formation and LTP

Kida S

cAMP response element-binding protein (CREB), a transcription factor, has been shown to play a central role in memory formation, and its involvement in this process has been investigated using a...
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Roles of Matrix Metalloproteinases and Their Targets in Epileptogenesis and Seizures

Mizoguchi , Yamada K

  • KMID: 2171153
  • Clin Psychopharmacol Neurosci.
  • 2013 Aug;11(2):45-52.
Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) remodel the pericellular environment by regulating the cleavage of extracellular matrix proteins, cell surface components, neurotransmitter receptors, and growth factors, which...
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