Korean J Pathol.  1986 Sep;20(3):395-398.

Malignant Histiocytosis: A case report

Affiliations
  • 1Department of Pathology, College of Medicine, Pusan National University, Pusan, Korea.

Abstract

We have recently experienced a clinically atypical case of malignant histiocytosis involving the spleen, ileum and bone marrow, in a 25-year-old Korean male. He was admitted to our hospital because of multiple purpuric lesions of skin which had been appearing since 2 years ago. Physical and laboratory examinations revealed marked splenomegaly with pancytopenia. With clinical impression of hypersplenism, splenectomy was performed. During the operation, the surgeons found a dark red mucosal lesion in the ileum incidentally, to resect the segment. Microscopic findings of the spleen and the ileal lesion showed extensive proliferation of atypical histiocytes, many of them phagocytosing numerous erythrocytes. Bone marrow biopsy was done for follow-up study, which showed increased cellularity with infiltration of atypical histiocytes.


MeSH Terms

Adult
Biopsy
Bone Marrow
Erythrocytes
Follow-Up Studies
Histiocytes
Histiocytic Sarcoma*
Humans
Hypersplenism
Ileum
Male
Pancytopenia
Skin
Spleen
Splenectomy
Splenomegaly
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