Korean J Obstet Gynecol.  2008 Jun;51(6):601-616.

Present status of worldwide clinical trials about uterine cervical cancer

• Kim SC

Abstract

Globally, cervical cancer is the second most common malignancy in women and a major cause of morbidity and mortality. Until recently, the greatest strides in reducing cervical cancer mortality have occurred with the advent and implementation of screening programs. Many important advances have also taken place in the diagnosis and treatment of cervical cancer. For young women who preserve fertility, radical trachelectomy was introduced. With advancing laparoscopic technique, radical hysterectomy using laparoscopy became operative. In radiation therapy, image-guided brachytherapy and intensity-modulated radiation therapy were introduced to optimized therapeutic effect and to reduce complication. Currently, in advanced stage cervical cancer, cisplatin-based concurrent chemoradiation was regarded as standard treatment. There is no consensus on optimal treatment modality in bulky IB2 and IIA tumor and metastatic, recurrent cancer.

Keyword

Cervical cancer; Clinical trials; Management

MeSH Terms

Brachytherapy
Consensus
Female
Fertility
Humans
Hypogonadism
Hysterectomy
Laparoscopy
Mass Screening
Mitochondrial Diseases
Ophthalmoplegia
Radiotherapy, Image-Guided
Uterine Cervical Neoplasms
Hypogonadism
Mitochondrial Diseases
Ophthalmoplegia