Korean J Obstet Gynecol.
2006 Aug;49(8):1706-1711.
+764 G/A Mutation of Inhibin-alpha Gene in Korean Patients with Idiopathic Premature Ovarian Failure
- Affiliations
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- 1Department of Obstetrics and Gynecology, Gachon Medical School, Korea.
- 2Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Korea. ymchoi@snu.ac.kr
- 3Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Korea.
- 4Healthcare System Gangnam Center, Seoul National University College of Medicine, Korea.
- 5Department of Obstetrics and Gynecology, Boramae Hospital, Korea.
- 6Department of Obstetrics and Gynecology, Pusan National University College of Medicine, Korea.
- 7Department of Obstetrics and Gynecology, University of Ulsan, Korea.
- 8Department of Obstetrics and Gynecology, Sunkyunkwan University School of Medicine, Korea.
- 9Department of Obstetrics and Gynecology, Dong-A University College of Medicine, Korea.
Abstract
OBJECTIVE
To evaluate the incidence of the +769 G/A mutation of inhibin-alpha gene in Korean patients with idiopathic premature ovarian failure. DESIGN: DNA analysis of the mutation.
METHODS
One hundred patients with idiopathic premature ovarian failure (POF) were recruited. Patient with known causes of premature ovarian failure were excluded: cytogenetic abnormalities, prior chemotherapy, prior bilateral oophorectomy and autoimmune disease, etc. DNA was extracted from peripheral blood and the +769 G/A variant of Inhibin-alpha gene (INH-alpha) was analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism using restriction enzyme BbvI.
RESULTS
We didn't find any case of +769 G/A variant in Inhibin-alpha gene in 100 Korean patients with idiopathic POF.
CONCLUSION
This result suggests that in contrary to the recent data reported on the Asian population, the +769 G/A variant in inhibin-alpha gene may not exist in Korean patients with idiopathic POF.
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