Korean J Obstet Gynecol.
2006 Jul;49(7):1463-1470.
MTA1 expression in epithelial ovarian neoplasm
- Affiliations
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- 1Department of Obstetrics and Gynecology, College of Medicine, Pusan National University, Pusan, Korea. msyoon@pusan.ac.kr
- 2Department of Pathology, College of Medicine, Pusan National University, Pusan, Korea.
Abstract
OBJECTIVE
MTA1 has been identified as a metastasis-promiting gene, and its gene expression is correlated with invasion and metastasis in several cancers. We examined MTA1 expression levels in epithelial ovarian neoplasm.
METHODS
Expression of MTA1 was evaluated by immunohistochemistry and tissue array in 53 benign tumors, 27 borderline tumors and 68 malignant tumors. The data was analyzed in reference to various clinicopathological parameters.
RESULTS
Increased expression of MTA1 was significantly correlated with histologic grade and FIGO stage. There was no relationship between MTA1 expression and age, histologic type, tumor size.
CONCLUSION
These results suggest that MTA1 is closely related to invasiveness and progression in epithelial ovarian neoplasm. The MTA1 could thus potentially provide information on the mechanism of cancer invasion and metastasis.
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