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Aquaporin 1 Is an Independent Marker of Poor Prognosis in Lung Adenocarcinoma

Yun S, Sun PL, Jin Y, Kim H, Park E, Park SY, Lee K, Lee K, Chung JH

BACKGROUND: Aquaporin 1 (AQP1) overexpression has been shown to be associated with uncontrolled cell replication, invasion, migration, and tumor metastasis. We aimed to evaluate AQP1 expression in lung adenocarcinomas and...
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Gastric biomarker study using proteomic method

Jeong SH, Lee YJ, Soon-Chan , Ha WS

Biomarker is defined as biological variables that correlate with biologic outcome. This review will discuss investigations into gastric cancer (GC) biomarkers by proteomic analysis. Proteomic analysis consists of 3 steps....
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Prognostic and Clinicopathological Significance of Transducer-Like Enhancer of Split 1 Expression in Gastric Cancer

Lee JH, Son MW, Kim KJ, Oh MH, Cho H, Lee HJ, Jang SH, Lee MS

PURPOSE: Transducer-like enhancer of split 1 (TLE1) is a member of the Groucho/TLE family of transcriptional co-repressors that regulate the transcriptional activity of numerous genes. TLE1 is involved in the...
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Prognostic Implication of Semi-quantitative Immunohistochemical Assessment of CD20 Expression in Diffuse Large B-Cell Lymphoma

Choi CH, Park YH, Lim JH, Choi SJ, Kim L, Park IS, Han JY, Kim JM, Chu YC

BACKGROUND: Immunohistochemical demonstration of CD20 in diffuse large B-cell lymphoma (DLBCL) is prerequisite not only for the diagnosis but also for assigning patients to rituximab-containing chemotherapy. However, little is known...
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High Notch1 Expression Correlates with Tumor Stage and Size in Clear Cell Renal Cell Carcinoma

Lee JN, Chun SY, Lee HJ, Ha YS, Kim HT, Yoo ES, Kwon TG, Kim TH

PURPOSE: Although the influence of Notch signaling on several types of malignancies has been studied, the role of Notch signaling in clear cell renal cell carcinoma (ccRCC) remains unclear. In...
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Prognostic Significance of Tissue Leptin Expression in Colorectal Cancer Patients

Jeong WK, Baek SK, Kim MK, Kwon SY, Kim HS

PURPOSE: Leptin is encoded by the ob gene and is involved in the control of food intake and energy expenditure. Recent studies have implicated leptin expression to be an indicator...
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RING Finger Proteins Are Involved in the Progression of Barrett Esophagus to Esophageal Adenocarcinoma: A Preliminary Study

Wang XW, Wei W, Wang WQ, Zhao XY, Guo H, Fang DC

BACKGROUND/AIMS: To investigate the differential expression of RING finger (RNF) proteins in Barrett esophagus (BE) and esophageal adenocarcinoma (EAC). METHODS: The differential expression of RNFs in normal esophagus (NE), BE, and...
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In-house Manual Construction of High-Density and High-Quality Tissue Microarrays by Using Homemade Recipient Agarose-Paraffin Blocks

Kim KH, Choi SJ, Choi YI, Kim L, Park IS, Han JY, Kim JM, Chu YC

  • KMID: 2277440
  • Korean J Pathol.
  • 2013 Jun;47(3):238-244.
BACKGROUND: Self-made tissue punches can be effectively used to punch holes in blank recipient paraffin blocks and extract tissue cores from the donor paraffin blocks for the low-cost construction of...
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An Immunohistochemical Study on the Expression of SUMO-2/3 in the Colorectal Carcinoma

Ham JH, Park J, Park DS, Lee SS, Yang SH, Jeong D

  • KMID: 2317655
  • Soonchunhyang Med Sci.
  • 2012 Dec;18(2):95-101.
OBJECTIVE: The incidence of colorectal carcinomas continues to rise in Korea due to the westernized life style. However, the precise colorectal carcinogenic mechanisms remain to be elucidated. The protein products...
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Construction of High-Density Tissue Microarrays at Low Cost by Using Self-Made Manual Microarray Kits and Recipient Paraffin Blocks

Choi CH, Kim KH, Song JY, Choi SJ, Kim L, Park IS, Han JY, Kim JM, Chu YC

  • KMID: 2012060
  • Korean J Pathol.
  • 2012 Dec;46(6):562-568.
BACKGROUND: Advances of tissue microarray (TMA) technology have enabled simultaneous in situ analysis of biomarker expression in a large number of archived pathology specimens. However, the relatively high cost of...
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The expressions of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) in the progression of invasive cervical cancer

Yu SY, Cho Y, Lim S, Park YH, Lee YW, Choi YH, Ro ES

  • KMID: 2273349
  • Korean J Obstet Gynecol.
  • 2008 May;51(5):527-533.
OBJECTIVE: To evaluate the expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) in the progression of cervical cancer. METHODS: A total 87 specimens of uterine cervix, representing 6...
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MTA1 expression in epithelial ovarian neoplasm

Yoon MS, Jang SK, Lee DH, Kim KH, Na YJ, Kim JY, Kim HW, Choi KU

  • KMID: 2272845
  • Korean J Obstet Gynecol.
  • 2006 Jul;49(7):1463-1470.
OBJECTIVE: MTA1 has been identified as a metastasis-promiting gene, and its gene expression is correlated with invasion and metastasis in several cancers. We examined MTA1 expression levels in epithelial ovarian...
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Tissue Array Methods for High-throughput Clinicopathologic Research

Lee HS, Kim WH

  • KMID: 2166085
  • Cancer Res Treat.
  • 2006 Feb;38(1):1-6.
Recent research in molecular biology has identified a significant number of novel markers, which may have diagnostic, prognostic and therapeutic significance. High-throughput tissue array method facilitates the validation of novel...
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Analysis of MTA1 gene expression for uterine cervical cancer by cDNA microarray and tissue array

Choi JK, Jang SK, Lee DH, Kim KH, Na YJ, Choi KU, Lee CH, Yoon MS

  • KMID: 2272733
  • Korean J Obstet Gynecol.
  • 2005 Nov;48(11):2607-2617.
OBJECTIVE: cDNA microarray and tissue array was utilized for the profiling of differentially expressed genes in uterine cervical squamous cell carcinoma. Metastasis associated 1 gene (MTA1) was investigated using these...
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Tissue Microarray Analysis of Fas and FasL Expressions in Human Non-small Cell Lung Carcinomas; with Reference to the p53 and bcl-2 Overexpressions

Myong NH

Lack of surface Fas expression is a main route for apoptotic resistance which is considered an important mechanism of tumorigenesis and tumor progression. Fas and FasL expressions in 110 non-small...
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Development of Multi-tissue Array Block for Diagnosis of Early Myocardial Infarction

Ha H, Li Z, Kim JH, Lee YS, Lee JB, Lee SD

  • KMID: 1849278
  • Korean J Leg Med.
  • 2003 Oct;27(2):23-30.
Tissue array contains hundreds or thousands tissues from different cases, and has been known useful for rapid analysis of markers in a large numbered work. This has mainly been used...
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