Korean J Obstet Gynecol.  2005 Oct;48(10):2462-2467.

Successful pregnancy and birth in a patient with panhypopituitarism caused by craniopharyngioma

• Koo YH
• Kim CH
• Lee SJ
• Lee HA
• Lee SR
• Kim SH
• Chae HD
• Kang BM

Abstract

Conceptions and uncomplicated pregnancies in patients with panhypopituitarism are rare especially after treatment of craniopharyngioma. We recently experienced a case of a patient with panhypopituitarism who became pregnant by gonadotropin therapy and gave birth to a healthy baby. A 33-year-old woman developed hypogonadotropic hypogonadism and diabetes insipidus because of craniopharyngioma which was surgically removed. Post-operative panhypopituitarism with diabetes insipidus was treated with adequate doses of L-thyroxin, prednisolone, desmopressin, medroxyprogesterone acetate (MPA), conjugated estrogen. To induce ovulation, human menopausal gonadotropin (hMG) and human chorionic gonadotropin (hCG) were administered, and a single intrauterine insemination (IUI) procedure was performed. The patient became pregnant and gave birth to a healthy baby. This case suggests that ovulation induction using gonadotropins and comprehensive hormone replacement therapy can result in the successful pregnancy in patients with panhypopituitarism after treatment of craniopharyngioma.

Keyword

Panhypopituitarism; Craniopharyngioma; Ovulation induction; Pregnancy

MeSH Terms

Adult
Chorionic Gonadotropin
Craniopharyngioma*
Deamino Arginine Vasopressin
Diabetes Insipidus
Estrogens
Female
Fertilization
Gonadotropins
Hormone Replacement Therapy
Humans
Hypogonadism
Insemination
Medroxyprogesterone Acetate
Ovulation
Ovulation Induction
Parturition*
Prednisolone
Pregnancy*
Chorionic Gonadotropin
Deamino Arginine Vasopressin
Estrogens
Gonadotropins
Medroxyprogesterone Acetate
Prednisolone