J Korean Endocr Soc.  2008 Jun;23(3):193-198. 10.3803/jkes.2008.23.3.193.

A Case of Slipped Capital Femoral Epiphysis in Association with Panhypopituitarism after Treatment of Craniopharyngioma

• Chung JO
• Hong SI
• Cho DH
• Chung DJ
• Chung MY

• KMID: 1479206
• DOI: http://doi.org/10.3803/jkes.2008.23.3.193

Abstract

Craniopharyngioma accounts for 2~5% of all primary intracranial neoplasms. It may present with a variety of manifestations including neurological, visual, and/or hypothalamic-pituitary dysfunction. Treatment options include radical surgery or radiotherapy, or a combination of these modalities. Craniopharyngioma ablation results in anterior and/or posterior pituitary hormone deficits. Slipped capital femoral epiphysis (SCFE), in which the femoral head slips downward and backward on the femoral neck at the epiphyseal plate, most commonly occurs during the rapid growth phase of puberty. Its actual cause is unknown, but the clinical association between SCFE and endocrine disorders is well known. We report a case of an adult male patient who developed SCFE in association with panhypopituitarism after treatment of a craniopharyngioma.

Keyword

craniopharyngioma; hypopituitarism; SCFE

MeSH Terms

Adult
Brain Neoplasms
Craniopharyngioma
Femur Neck
Growth Plate
Head
Humans
Hypopituitarism
Male
Puberty
Slipped Capital Femoral Epiphyses

Figure

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  Figure 1 Frontal view of external genitalia of the patient showed hypoplastic genitalia with no pubic hair. Penis was 3 cm in length. The volume of right testis was 2 cc, and that of left was 1 cc.

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  Figure 2 A. Preoperative both hip A-P view showed downward and posterior slipping of the left femoral epiphysis. B. Postoperative both hip A-P view showed internal fixation with cannulated screw of both femoral epiphysis.

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  Figure 3 Hand X-ray showed bone age corresponding with 12 years. All carpal bones were shown. The epiphyseal growth plates of metacarpal, phalangeal, distal ulnar and radial bone were not closed.

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  Figure 4 A. Preoperative sagittal T1 - weighted sellar MRI showed 1.8 cm sized well circumscribed mass with suprasellar extension. B. 12 years later, sagittal T1 - weighted sellar MRI showed empty sella with no remnant mass.

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