Korean J Obstet Gynecol.  2003 Apr;46(4):795-801.

Relationship Between Poly (A) Microsatellite in Vitamin D Receptor Gene, and Bone Mineral Density in Postmenopausal Korean Women

• Kim JG
• Kwon JH
• Kim SH
• Choi YM
• Moon SY
• Lee JY

Abstract

OBJECTIVE
To investigate a poly (A) microsatellite in vitamin D receptor (VDR) gene and to evaluate its relationship with bone mineral density (BMD) in postmenopausal Korean women.
METHODS
The poly (A) polymorphism was analyzed in 417 postmenopausal Korean women. Serum CrossLaps (CTX), bone alkaline phosphatase (BAP), osteocalcin and 1,25 (OH)2 vitamin D3 levels were measured by enzyme linked immunosorbent assay and immmunoassay and BMD at the lumbar spine and proximal femur by dual energy X-ray absorptiometry.
RESULTS
When alleles of poly (A) microsatellite were classified into two groups, long (L: A18-22) and short (S: A12-17), based upon the length of the repeat, the prevalence of SS was 1.4%, LS 10.1%, and LL 88.5%. There was a significant correlation between BMD and poly (A) polymorphism. BMD at the femoral neck and trochanter in LS genotype was significantly lower than that in LL genotype. LL genotype was more prevalent in women with normal BMD compared with women with low bone mass while LS genotype was more prevalent in the latter group. There were no significant associations between the adjusted levels of the bone markers, 1,25 (OH)2 vitamin D3 and poly (A) genotypes.
CONCLUSION
The VDR gene poly (A) polymorphism is one of genetic factors which may affect BMD in Korean women.

Keyword

Postmenopausal women; Poly (A) polymorphism; BMD; Vitamin D3

MeSH Terms

Absorptiometry, Photon
Alkaline Phosphatase
Alleles
Bone Density*
Cholecalciferol
Enzyme-Linked Immunosorbent Assay
Female
Femur
Femur Neck
Genotype
Humans
Microsatellite Repeats*
Osteocalcin
Prevalence
Receptors, Calcitriol*
Spine
Vitamin D*
Vitamins*
Alkaline Phosphatase
Cholecalciferol
Osteocalcin
Receptors, Calcitriol
Vitamin D
Vitamins