Korean J Obes.
2014 Sep;23(3):150-155. 10.7570/kjo.2014.23.3.150.
Exosomes and Microvesicles as Biomarkers in Metabolic Diseases
- Affiliations
-
- 1Department of Biochemistry-Molecular Biology, School of Medicine, Eulji University, Daejoen, Korea. lskendo@hanmail.net
- 2Department of Internal Medicine, Division of Endocrinology, Eulji University Hospital, Daejeon, Korea.
- KMID: 2271123
- DOI: http://doi.org/10.7570/kjo.2014.23.3.150
Abstract
- Currently used biomarkers in metabolic diseases are neither sufficient for monitoring the stage of disease development nor for monitoring differences among patients with different underlying pathogenetic pathways and pathogenesis. Exosomes and microvesicles, which are released from a wide variety of tissues, cells and blood cells in response to normal or stressed state, and under pathogenic conditions, contain various proteins, mRNAs, miRNAs and etc. that reflect the diverse functional and dysfunctional states of the releasing cells and tissues. Therefore, exosomes and microvesicles could be the next potential new biomarkers that could help predict, diagnose, treat and monitor prognosis of metabolic diseases as in obesity. Exosomes and microvesicles may overcome limitations of current biomarkers once their characteristics are clarified and methods for easier detection are developed.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Exosomes as the source of biomarkers of metabolic diseases
- Extracellular Vesicles as a Source of Urological Biomarkers: Lessons Learned From Advances and Challenges in Clinical Applications to Major Diseases
- Extracellular vesicles in kidneys and their clinical potential in renal diseases
- Exosomes: Nomenclature, Isolation, and Biological Roles in Liver Diseases
- Quantitative Analysis of Exosomes From Murine Lung Cancer Cells by Flow Cytometry
