Korean J Obes.  2014 Sep;23(3):150-155. 10.7570/kjo.2014.23.3.150.

Exosomes and Microvesicles as Biomarkers in Metabolic Diseases

Affiliations
  • 1Department of Biochemistry-Molecular Biology, School of Medicine, Eulji University, Daejoen, Korea. lskendo@hanmail.net
  • 2Department of Internal Medicine, Division of Endocrinology, Eulji University Hospital, Daejeon, Korea.

Abstract

Currently used biomarkers in metabolic diseases are neither sufficient for monitoring the stage of disease development nor for monitoring differences among patients with different underlying pathogenetic pathways and pathogenesis. Exosomes and microvesicles, which are released from a wide variety of tissues, cells and blood cells in response to normal or stressed state, and under pathogenic conditions, contain various proteins, mRNAs, miRNAs and etc. that reflect the diverse functional and dysfunctional states of the releasing cells and tissues. Therefore, exosomes and microvesicles could be the next potential new biomarkers that could help predict, diagnose, treat and monitor prognosis of metabolic diseases as in obesity. Exosomes and microvesicles may overcome limitations of current biomarkers once their characteristics are clarified and methods for easier detection are developed.

Keyword

Exosomes; Microvesicles; Biomarkers; Metabolic diseases

MeSH Terms

Biomarkers*
Blood Cells
Exosomes*
Humans
Metabolic Diseases*
MicroRNAs
Obesity
Prognosis
RNA, Messenger
MicroRNAs
RNA, Messenger
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