Korean J Obstet Gynecol.  2001 Feb;44(2):405-408.

A Case of premature ovarian failure developed from oral medication of cyclophosphamide for the treatment of pemphigus vulgaris

• Sung YJ
• Lee YH
• Cha DH
• Kim JY
• Hong SO

Abstract

Pemphigus vulgaris is autoimmune disease characterized by acantholysis and blister formation in the skin and mucosa. The introduction of corticosteroids has greatly reduced mortality, and a number of immunosuppressive agents, such as azathioprine and cyclophosphamide are recommended as adjuncts to oral steroids. A 38-year-old female patient of pemphigus vulgaris has been managed with daily oral cyclophosphamide as adjunct to prednisolone for about 11 months, and then transfered to our department due to amenorrhea for 4 months. Hormonal profile of FSH, LH and estradiol revealed in postmenopausal range and follow-up results of hormonal profile were not changed, and amenorrhea continues for total 13 months until now. So we report a case of premature ovarian failure complicated by long-term oral administration of cyclophosphamide.

Keyword

Premature ovarian failure; Cyclophosphamide; Pemphigus vulgaris

MeSH Terms

Acantholysis
Administration, Oral
Adrenal Cortex Hormones
Adult
Amenorrhea
Autoimmune Diseases
Azathioprine
Blister
Cyclophosphamide*
Estradiol
Female
Follow-Up Studies
Humans
Immunosuppressive Agents
Mortality
Mucous Membrane
Pemphigus*
Prednisolone
Primary Ovarian Insufficiency*
Skin
Steroids
Adrenal Cortex Hormones
Azathioprine
Cyclophosphamide
Estradiol
Immunosuppressive Agents
Prednisolone
Steroids