Korean J Obstet Gynecol.  2001 Feb;44(2):296-301.

The Concentration of Estradiol, Testosterone and Insulin-like Growth Factor-I in Follicular Fluid of Patients with Polycystic Ovarian Syndrome Undergoing Controlled Ovarian Hyperstimulation

• Kim SH
• Kwon HE
• Park EJ
• Chae HD
• Kim CH
• Kang BM
• Chang YS

Abstract

OBJECTIVE
To evaluate microenvironment of follicular fluid, such as estradiol(E2), testosterone(T), and insulin-like growth factor-I(IGF-I) of patients with polycystic ovary syndrome(PCOS) undergoing controlled ovarian hyperstimulation(COH) for in vitro fertilization and embryo transfer(IVF-ET).
MATERIALS AND METHODS
From January 1996 to June 1998, follicular concentrations of E2, T, and IGF-I on the day of transvaginal ovum aspiration were measured in 40 patients undergoing COH for IVF-ET. The patients were grouped into the control(n=20) and the PCOS(n=20) groups. Statistical analysis was performed using Student's t-test, Fisher's exact test, and X2 test as appropriate. Statistical significance was defined as p<0.05.
RESULTS
There were no significant differences in the follicular concentrations of E2, T, and IGF-I between the control and the PCOS groups.
CONCLUSION
IGF-I might be not a main component of the local regulatory mechanisms involved in the pathogenesis of PCOS.

Keyword

Polycystic ovarian syndrome; Follicular fluid; Insulin-like growth factor-I; Estrogen; Testosterone

MeSH Terms

Embryonic Structures
Estradiol*
Estrogens
Female
Fertilization in Vitro
Follicular Fluid*
Humans
Insulin-Like Growth Factor I
Ovary
Ovum
Polycystic Ovary Syndrome*
Testosterone*
Estradiol
Estrogens
Insulin-Like Growth Factor I
Testosterone