Korean J Obstet Gynecol.
2005 Feb;48(2):376-383.
Correlation of vascular endothelial growth factor concentrations in follicular fluid with the ovarian response as well as the age in women undergoing controlled ovarian hyperstimulation
- Affiliations
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- 1Department of Obstetrics and Gynecology, Hanmaeum Hospital, Changwon, Korea.
- 2Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Busan, Korea. kuslee@pusan.ac.kr
Abstract
OBJECTIVE
To elucidate the correlation of vascular endothelial growth factor (VEGF) concentrations in follicular fluid (FF) with the ovarian response as well as the age in women undergoing controlled ovarian hyperstimulation (COH).
METHODS
This study was performed in 72cycles who underwent COH for in vitro fertilization at infertility clinic of Changwon Hanmaeum Hospital and Pusan National University Hospital from Aug., 2003 to Dec., 2003. Each FF was collected at the oocyte retrieval according to the follicular size and VEGF concentrations in FF were assessed. We analyzed the correlation of VEGF concentrations in FF with ovarian response as well as the age in women undergoing COH.
RESULTS
In 72cycles, the clinical pregnancy rate was 37.5% (27cycles). There were no significant differences in patient's age, ampules of gonadotropin used, estradiol (E2) level on the day of hCG administration, the number of oocyte retrieved, and fertilization rate between pregnant and nonpregnant groups. However, positive correlation was found between the follicular size and VEGF concentrations in FF in pregnant and nonpregnant groups. No significant correlation was found between age and VEGF concentrations in FF. There were no significant differences in the VEGF concentrations in FF between pregnant and nonpregnant women by age.
CONCLUSION
These results suggest that VEGF concentrations in FF cannot be the marker for the prediction of ovarian response, and have no correlation with all parameters of COH including patients' age with exception for the follicular size.
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