Korean J Nutr.  2006 Jul;39(5):444-450.

The Effects on Antimicrobial and Cytotoxicity of Hijikia Fusiformis Fraction

• Shon JH
• Kang DY
• Oh HC
• Jung BM
• Kim MH
• Shin MO
• Bae SJ

Abstract

In this study, we investigated antimicrobial and cytotoxicity effects to each fraction extracted from Hizikia fusiformis (HF), which were extracted methanol (HFM)and then the extract was fractionated into four different types: hexane (HFMH), methanol (HFMM), butanol (HFMB) and aquous (HFMA) partition layers. We determined the cytotoxic effect of these layers on human cancer cells by MTT assay. Among various partition layers of HF, the HFMB and HFMM were showed the strong cytotoxic effects on cancer cell lines we used. The quinone reductase (QR) induced activity of the HFMB on HepG2 cells at 150 microgram/mL concentration was 2.63 times more effective compared to the control value of 1.0. Although further studies are needed, the present work suggests that HF maybe a chemopreventive agent for the treatment of human cancer cells.

Keyword

cytotoxicity; quinone reductase; Hizikia fusiformis (HF),cancer cell lines

MeSH Terms

Cell Line
Hep G2 Cells
Humans
Methanol
NAD(P)H Dehydrogenase (Quinone)
Methanol
NAD(P)H Dehydrogenase (Quinone)