Korean J Nutr.  2004 Jun;37(5):347-351.

Supplementary Effect of gamma-Oryzanol on Lipid Metabolism in Diabetic KK Mice

• Lee SH
• Chun HK
• Park HJ
• Lee YS

Abstract

This study was carried out to investigate the supplementary effects of gamma-oryzanol extracted from rice bran on lipid metabolism in diabetic mice. We supplied 2 kinds of experimental diets (CO without and GO with 0.2% gamma-oryzanol) to diabetic mice for 8 weeks. Diet intake, body weight, organ weight, contents of serum and hepatic lipid profiles, and fecal lipid levels were measured. Though there was no significant difference in diet intake, body weight change and organ weight between experimental groups, the concentration of serum total cholesterol and hepatic total lipid, total cholesterol and HMG-CoA reductase activity was significantly lower in GO group treated with 0.2% gamma-oryzanol of diet than CO group after supplementary period of experimental diets. And total lipid, triglyceride, total cholesterol, and bile acid levels excreted to feces were significantly higher in GO group than CO group. These results suggest that gamma-oryzanol decrease the serum and hepatic lipid levels by lowing HMG-CoA reductase activity or increasing the contents of fecal lipid in diabetic KK mice.

Keyword

gamma-oryzanol; rice bran; diabetic mouse; lipid metabolism

MeSH Terms

Animals
Bile
Body Weight
Body Weight Changes
Cholesterol
Diet
Feces
Lipid Metabolism*
Mice*
Organ Size
Oxidoreductases
Triglycerides
Cholesterol
Oxidoreductases