Korean J Med.  2014 Oct;87(4):484-490. 10.3904/kjm.2014.87.4.484.

A Case Report of Recurrent Malignant Paraganglioma with Lung and Spine Metastasis that Occurred Sixteen Years after Primary Tumor Excision

• Moon ES
• Min HS
• Jung CH
• Choi JH
• Kim JS
• Yoo HJ
• Choi SY

• KMID: 2269226
• DOI: http://doi.org/10.3904/kjm.2014.87.4.484

Abstract

Paragangliomas are rare tumors that arise from the extra-adrenal chromaffin cells, and malignancy is defined by the presence of metastases to sites that normally lack chromaffin tissue. The main therapeutic targets are tumor reduction and control of excessive catecholamine secretion. Currently, the adjuvant therapy to surgery is radiotherapy treatment using high-dose MIBG; chemotherapy is currently evolving. We report herein a case of malignant paraganglioma with lung and spine metastasis that occurred 16 years after primary tumor excision and was treated with high dose MIBG radiotherapy and chemotherapy.

Keyword

Malignant paraganglioma, Lung metastasis, Spine metastasis; Metaiodobenzylguanidine; Chemotherapy

MeSH Terms

3-Iodobenzylguanidine
Chromaffin Cells
Drug Therapy
Lung*
Neoplasm Metastasis*
Paraganglioma*
Radiotherapy
Spine*
3-Iodobenzylguanidine