Korean J Med.  2015 Jan;88(1):78-82. 10.3904/kjm.2015.88.1.78.

A Case of Pituitary Macroadenoma Concurrently Diagnosed in a Patient Undergoing Antipsychotic Treatment

• Kim BS
• Kim JS
• Ryu HK
• Park JW
• Hyun SA
• Kang JW
• Choi YJ

• KMID: 2269175
• DOI: http://doi.org/10.3904/kjm.2015.88.1.78

Abstract

Antipsychotics are the drug of choice for patients with schizophrenia, but they can induce hyperprolactinemia and growth of pituitary adenomas by blocking dopamine 2 receptors in the pituitary gland. In contrast, the medical treatment for a prolactinoma is a dopamine agonist. Therefore, managing a patient concurrently diagnosed with a prolactinoma and psychosis is challenging. We describe a patient with schizophrenia who was diagnosed with a prolactinoma. We changed his neuroleptic to quetiapine and prescribed bromocriptine for the prolactinoma. As a result, the patient was successfully treated with a dopamine agonist and antipsychotic without psychotic exacerbation. Our case suggests that dopamine agonists can be administrated to patients with schizophrenia and a prolactinoma without adversely affecting their psychopathological status.

Keyword

Prolactinoma; Bromocriptine; Antipsychotic agents

MeSH Terms

Antipsychotic Agents
Bromocriptine
Dopamine
Dopamine Agonists
Humans
Hyperprolactinemia
Pituitary Gland
Pituitary Neoplasms
Prolactinoma
Psychotic Disorders
Schizophrenia
Quetiapine Fumarate
Antipsychotic Agents
Bromocriptine
Dopamine
Dopamine Agonists