Korean J Med.  2015 Jul;89(1):122-126. 10.3904/kjm.2015.89.1.122.

A Case of Rheumatoid Arthritis Accompanied by Thrombotic Thrombocytopenic Purpura

Affiliations
  • 1Division of Rheumatology, Department of Internal Medicine, Maryknoll Medical Center, Busan, Korea. ete@lycos.co.kr

Abstract

Thrombotic thrombocytopenic purpura (TTP) is a blood coagulation disorder that damages numerous organs, including the kidney, heart and brain. Features indicative of TTP include thrombocytopenia, microangiopathic hemolytic anemia, neurologic symptoms, kidney failure and fever. Infections, toxins, pregnancy and, rarely, autoimmune diseases are all known to be associated with TTP. We encountered a rare case of rheumatoid arthritis accompanied by TTP following tympanoplasty. The patient's confusion, thrombocytopenia and renal failure all improved after plasmapheresis and high-dose glucocorticoid therapy, but she eventually expired due to sepsis. We report on this case herein and also review the relevant literature.

Keyword

Thrombotic thrombocytopenic purpura; Rheumatoid arthtiris; Plasmapheresis

MeSH Terms

Anemia, Hemolytic
Arthritis, Rheumatoid*
Autoimmune Diseases
Blood Coagulation Disorders
Brain
Fever
Heart
Kidney
Neurologic Manifestations
Plasmapheresis
Pregnancy
Purpura, Thrombotic Thrombocytopenic*
Renal Insufficiency
Sepsis
Thrombocytopenia
Tympanoplasty
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