Korean J Med.  2015 Aug;89(2):243-248. 10.3904/kjm.2015.89.2.243.

Fatal PTLD Accompanied by Rapid Lymphocyte Proliferation in the Early Phase of Allogeneic HSCT

• Lee JY
• Kim G
• Lee E
• Park SH
• Kim JS
• Cheong JW
• Min YH

• KMID: 2269038
• DOI: http://doi.org/10.3904/kjm.2015.89.2.243

Abstract

Post-transplant lymphoproliferative disorder (PTLD) is a spectrum of clinically and morphologically heterogeneous lymphoid proliferations of various clonal compositions that are observed after hematopoietic stem cell transplantation (HSCT) or solid organ transplantation. The majority of PTLD cases are associated with Epstein-Barr virus (EBV) infection, while overt peripheral blood (PB) or bone marrow (BM) involvement in PTLD is uncommon in early lesions. We report a 38-year-old woman with EBV-related PTLD, with BM and PB involvement, who presented with peripheral lymphocytosis as an early lesion 1 month after haploidentical HSCT for Philadelphia chromosome-positive acute lymphoblastic leukemia was performed during first complete remission. Although PB or BM involvement of PTLD after HSCT is uncommon in early lesions, peripheral lymphocytosis can be an initial presenting manifestation of PTLD, as in this case.

Keyword

Epstein-Barr virus infections; Transplantation; Lymphoproliferative disorder

MeSH Terms

Adult
Bone Marrow
Epstein-Barr Virus Infections
Female
Hematopoietic Stem Cell Transplantation
Herpesvirus 4, Human
Humans
Lymphocytes*
Lymphocytosis
Lymphoproliferative Disorders
Organ Transplantation
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Transplantation
Transplants