Korean J Nutr.  2011 Aug;44(4):284-291. 10.4163/kjn.2011.44.4.284.

Effects of Water Extracts of Red Pepper Seeds Powder on Antioxidative Enzyme Activities and Oxidative Damage in Rats Fed High-Fat and High-Cholesterol Diets

• Kim YN
• Ku KH
• Kang SK
• Choi JH

• KMID: 2268544
• DOI: http://doi.org/10.4163/kjn.2011.44.4.284

Abstract

The purpose of the present study was to examine the effects of water extracts from red pepper seeds powder on antioxidative enzyme activities and oxidative damage in groups of rrats fed high-fat and high-cholesterol diets group (HFC). The Rrats were divided into the following five experimental groups which are : composed ofa normal diet group, a high fat.high cholesterol diet group, and a high fat.high cholesterol diet group supplemented with different amounts contents (1%, 2% and 4%) of red pepper seeds powder water extracts supplemented groups (HFCW1, HFCW2 and HFCW4, respectively). Body weight gains and food intake were lower ofin the red pepper seed water extracts groups were lower than those inof the HFC group. Hepartic xanthine oxidase (XOD) activity was decreased in the HFCW2 and HFCW4 groups compared to the HFC group. Hepartic glutathione peroxidase (GSH-px) activitiyactivity was increased in the HFCW4 group compared to the HFC group. Hepatic superoxide radicals within the mitochondria and microsomes of cells were significantly reduced in the HFCW2 and HFCW4 groups compared to the HFC group. Hepartic hydrogen peroxide in the cytosol was significantly reduced in the HFCW3 and HFCW4 groups compared to the HFC group. Hepatic carbonyl values in the microsomes and mitochondria were significantly reduced in the HFCW4 group compared to the HFC group. Hepartic thiobarbituric acid reaction substance (TBARS) activity was decreased in the HFCW2 group compared to the HFC group. These results suggest that water extracts of red pepper seeds powder may reduce oxidative damage by activation of antioxidative defense systems in rats fed high fat.high cholesterol diets.

Keyword

red pepper seeds powder; antioxidative system; high cholesterol; oxidative damage; free radical

MeSH Terms

Animals
Body Weight
Capsicum
Cholesterol
Cytosol
Diet
Eating
Glutathione Peroxidase
Hydrogen Peroxide
Microsomes
Mitochondria
Rats
Seeds
Superoxides
Thiobarbiturates
Water
Xanthine Oxidase
Cholesterol
Glutathione Peroxidase
Hydrogen Peroxide
Superoxides
Thiobarbiturates
Water
Xanthine Oxidase

Figure

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  Fig. 1 Effects of water extracts from red pepper seeds on hepatic hydrogen peroxide contents in rats fed high fat·high cholesterol diets. All values are the means ± SE (n = 10). Those with different superscript letters are significantly different at p < 0.05 by Tukey's test.

• 

  Fig. 2 Effects of water extracts from red pepper seeds on hepatic carbonyl value contents in rats fed high fat·high cholesterol diets. All values are the means ± SE (n = 10). Those with different superscript letters are significantly different at p < 0.05 by Tukey's test.

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