Korean J Nutr.  2010 Feb;43(1):12-25. 10.4163/kjn.2010.43.1.12.

Bioavailability and Digestibility of Organic Calcium Sources by Bone Health Index

• Han J
• Kim E
• Cheong M
• Chee S
• Chee K

• KMID: 2267960
• DOI: http://doi.org/10.4163/kjn.2010.43.1.12

Abstract

This study was carried out to evaluate the bioavailabilities and the digestibilities of oligopeptide chelated (peptide-Ca), anchovy bone (anchovy-Ca) and methionine hydroxyl analogue (MHA-Ca) calcium compared to those of calcium carbonate in rats. In exp1, CaCO3, were added to the basal diet at level of 0, 30 and 60% calcium of the AIN-93G diet. In test groups, peptide-Ca, anchovy-Ca and MHA-Ca, were added to the basal diet to provide calcium at the level of 40% of AIN-93G. In exp1, the bioavailabilities were evaluated from the regression equation of the ratios of theological/actual calcium intakes of each dietary treatment. In exp2, urine and feces was to evaluate the true- and apparent digestibility and apparent retention. In exp1, Ca-60% group had higher bone mineral density (BMD), bone mineral content (BMC) and bone breaking strength (BBS) than those of the other standard groups. The bone weight and ash content of the peptide-Ca and anchovy-Ca groups were significantly higher than those of the MHA-Ca. Bone calcium content were not significantly different from the test group. The bioavailability of the MHA-Ca group was shown higher BMD (71%), BS (38%) and BBS (27%) compared to another control group. But the regression coefficient for BMD, BS and BBS were lower compare with that of bone ash and BMC. In exp2, the true- and apparent digestibility of test groups were shown to over 90%. Peptide-Ca was not significantly different from other test group, but digestibility and retention were higher compare to other test groups. In conclusion, peptide-Ca, anchovy-Ca and MHA-Ca improved Ca bioavailability in the rats. The compounds were higher Ca digestibility compared with those of CaCO3. It is assumed that difference of digestibility for test groups may be correlated to the bioavailability of test groups in BMD, BMC, BS, BBS and bone ash respectively.

Keyword

calcium; bioavailability; digestibility; bone calcium; rat

MeSH Terms

Animals
Biological Availability
Bone Density
Calcium
Calcium Carbonate
Diet
Feces
Methionine
Minerals
Rats
Retention (Psychology)
Calcium
Calcium Carbonate
Methionine
Minerals

Figure

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  Fig. 1 Relationship between BMD and Ca intake from calcium standard diets groups.

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  Fig. 2 Relationship between BMC and Ca intake from calcium standard diets groups.

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  Fig. 3 Relationship between BS and Ca intake from calcium standard diets groups.

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  Fig. 4 Relationship between BBS and Ca intake from calcium standard diets groups.

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  Fig. 5 Relationship between bone ash (%) and Ca intake (mg/rat/day) from calcium standard diets groups.

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