Korean J Med.  2013 Dec;85(6):551-558.

Pathophysiology of Colon Diverticulum

• Kim SE

Abstract

Although the pathogenesis of diverticulum remains unclear, traditionally it has been thought to result from structural abnormalities of the colonic wall, deficiencies of dietary fiber, or disordered intestinal motility. More recently, new pathophysiologic factors including inflammation, gut flora, neurotransmitters, visceral hypersensitivity, and chemical mediators are proposed, and their mechanism of interactions in developing diverticulum is quite complex and currently poorly understood. Future studies are needed to find out the multifaceted pathogenesis of diverticulum, ultimately for the treatment and prevention of disease.

Keyword

Diverticulum; Colon; Pathogenesis

MeSH Terms

Colon*
Dietary Fiber
Diverticulum
Diverticulum, Colon*
Gastrointestinal Motility
Hypersensitivity
Inflammation
Neurotransmitter Agents
Neurotransmitter Agents