Ann Dermatol.  2013 Aug;25(3):352-355. 10.5021/ad.2013.25.3.352.

Touraine-Soulente-Gole Syndrome: A Rare Case Report and Review of the Literature

• Kumar S
• Sidhu S
• Mahajan BB

• KMID: 2265877
• DOI: http://doi.org/10.5021/ad.2013.25.3.352

Abstract

Touraine-Soulente-Gole Syndrome (TSG) or pachydermoperiostosis is a rare disorder characterized by pachydermia, periostosis & digital clubbing. Herein, we report a case of a 27 year old male, with the looks of a 47 year old. He presented with excessive wrinkling on his face since past 8 years. TSG syndrome was suspected and examined by histopathological, endocrinological and radiological studies for the confirmation of clinical diagnosis.

Keyword

Hypertrophic osteoarthropathy; Pachydermoperiostosis; Touraine-soulente-gole syndrome

MeSH Terms

Humans
Male
Osteoarthropathy, Primary Hypertrophic

Figure

• 

  Fig. 1 Cutis verticis gyrata.

• 

  Fig. 2 Leonine faces.

• 

  Fig. 3 Broadening of hands and fingers.

• 

  Fig. 4 Periosteal reaction along the shaft.

• 

  Fig. 5 Histopathological examination showing hyperplasia epidermal and dermal changes (H&E, ×10).

Reference

1. Castori M, Sinibaldi L, Mingarelli R, Lachman RS, Rimoin DL, Dallapiccola B. Pachydermoperiostosis: an update. Clin Genet. 2005; 68:477–486.

2. Lowenthal MN, Tombak A, Lowenthal A. Secondary hypertrophic osteoarthropathy (HOA) mimicking primary HOA (pachydermoperiostitis or Touraine-Solente-Golé) syndrome. Isr Med Assoc J. 2004; 6:64.

3. Jajic I, Jajic Z. Prevalence of primary hypertrophic osteoarthropathy in selected population. Clin Exp Rheumatol. 1992; 10:73.

4. Resnick D. Enostosis, hyperostosis, and periostitis. In : Resnick D, Kransdorf MJ, editors. Bone and joint imaging. 3rd ed. Philadelphia, PA: Elsevier Saunders;2005. p. 1433–1435.

5. Oikarinen A, Palatsi R, Kylmäniemi M, Keski-Oja J, Risteli J, Kallioinen M. Pachydermoperiostosis: analysis of the connective tissue abnormality in one family. J Am Acad Dermatol. 1994; 31:947–953.

6. Silveira LH, Martínez-Lavín M, Pineda C, Fonseca MC, Navarro C, Nava A. Vascular endothelial growth factor and hypertrophic osteoarthropathy. Clin Exp Rheumatol. 2000; 18:57–62.

7. Bianchi L, Lubrano C, Carrozzo AM, Iraci S, Tomassoli M, Spera G, et al. Pachydermoperiostosis: study of epidermal growth factor and steroid receptors. Br J Dermatol. 1995; 132:128–133.

8. Uppal S, Diggle CP, Carr IM, Fishwick CW, Ahmed M, Ibrahim GH, et al. Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy. Nat Genet. 2008; 40:789–793.

9. Touraine A, Solente G, Gole L. Un syndrome osteodermopathique: la pachydermie plicaturee avec pachyperiostose ds extremites. Presse Med. 1935; 43:1820–1824.

10. Alves AP, Holanda Filha JG, Jerônimo FT. Eyelid ptosis associated with pachydermoperiostosis: case report. Arq Bras Oftalmol. 2005; 68:401–404.

11. Cooper RG, Freemont AJ, Riley M, Holt PJ, Anderson DC, Jayson MI. Bone abnormalities and severe arthritis in pachydermoperiostosis. Ann Rheum Dis. 1992; 51:416–419.

12. Hedayati H, Barmada R, Skosey JL. Acrolysis in pachydermoperiostosis. Primary or idiopathic hypertrophic osteoarthropathy. Arch Intern Med. 1980; 140:1087–1088.

13. Jajic Z, Jajic I, Nemcic T. Primary hypertrophic osteoarthropathy: clinical, radiologic, and scintigraphic characteristics. Arch Med Res. 2001; 32:136–142.

14. Schumacher HR Jr. Hypertrophic osteoarthropathy: rheumato logic manifestations. Clin Exp Rheumatol. 1992; 10:Suppl 7. 35–40.

15. Seyhan T, Ozerdem OR, Aliagaoglu C. Severe complete pachydermoperiostosis (Touraine-Solente-Golé syndrome). Dermatol Surg. 2005; 31:1465–1467.

16. George L, Sachithanandam K, Gupta A, Pulimood S. Frontal rhytidectomy as surgical treatment for pachydermoperiostosis: a case report. J Dermatolog Treat. 2008; 19:61–63.

17. Brüner S, Frerichs O, Raute-Kreinsen U, Fansa H. Correction of finger clubbing in primary hypertrophic osteoarthropathy (Touraine-Solente-Gole syndrome). Handchir Mikrochir Plast Chir. 2007; 39:135–138.

18. Goyal S, Schwartz AR, Richards GM, Goyal R. Pachydermoperiostosis [Internet]. New York (NY): Medscape;updated on 2008 Apr 30. Available from: http://www.emedicine.com.