Korean J Nutr.
2008 Jul;41(5):402-413.
Apolipoprotein E Phenotypes and the Relationship Among Lipid Levels, Nutrient Intakes, Lifestyles and Risk Factors Between Subjects with and without Hyperlipidemic Risk
- Affiliations
-
- 1Graduate School of Education, Chung Ang University, Seoul 156-756, Korea.
- 2Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd, Seoul 135-791, Korea. choimd@khnp.co.kr
- 3Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 446-701, Korea.
Abstract
- This study was performed to investigate Apolipoprotein E phenotypes and the relationship among lipid levels, nutrient intakes, lifestyles and risk factors between subjects with and without hyperlipidemic risk. The data were collected from 675 industrial male workers who had completed annual medical examination. Compared to the normal group, the hyperlipidemic risk group in Apo E3 and E4 had significantly higher BMI (p < 0.05) and showed significantly higher body fat (%), waist circumference and WHR in all types of Apo E (p < 0.05). In addition, the hyperlipidemic risk group had significantly higher total cholesterol, LDL-cholesterol, triglyceride and AI than the normal group in all types of Apo E (p < 0.05). Intakes of protein, calcium, phosphorus, iron, vitamin A, vitamin B1, vitamin B2, vitamin C and niacin in Apo E3 were significantly lower in the hyperlipidemic risk group than in the normal group (p < 0.05). In the logistic regression analysis, after adjustment for other factors, Apo E2 + E4, waist and WHR were the significant risk factors associated with hyperlipidemia, but protein intakes were associated with significantly lower risks of hyperlipidemia (p < 0.05). In conclusion, genetic factor (Apo E2 or Apo E4), anthropometric index and nutrient intake seem to influence hyperlidemic risk. Further studies and efforts will be needed to evaluate the independent relationships among hyperlipidemic risk factors.
MeSH Terms
-
Adipose Tissue
Apolipoprotein E2
Apolipoprotein E3
Apolipoproteins
Apolipoproteins E
Ascorbic Acid
Calcium
Cholesterol
Humans
Hyperlipidemias
Iron
Life Style
Logistic Models
Male
Niacin
Phenotype
Phosphorus
Riboflavin
Risk Factors
Thiamine
Vitamin A
Waist Circumference
Apolipoprotein E2
Apolipoprotein E3
Apolipoproteins
Apolipoproteins E
Ascorbic Acid
Calcium
Cholesterol
Iron
Niacin
Phosphorus
Riboflavin
Thiamine
Vitamin A
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