Korean J Med.  2012 Jan;82(1):115-118.

Fatal Hypersensitivity Reactions Induced by Re-Administration of Rifampin in an Immunocompetent Patient with Tuberculous Lymphadenopathy

• Kim Y
• Yim SY
• Bae SI
• Ahn JH
• Chang WG
• Sohn JW
• Kim MJ

Abstract

A 44-year-old patient who had been diagnosed with tuberculous lymphadenopathy came to our hospital with a rash. He began to take antituberculous medications, but the next day, a rash appeared and persisted for one week. When he came to the hospital, he had already stopped the medication by his own decision. We stopped all drugs and reintroduced one drug at a time. After re-administration of rifampin, anaphylactic shock and subsequent acute renal failure and rhabdomyolysis occurred. Intensive care was performed, but the patient died 60 h after the first hypersensitive reaction that occurred due to rifampin. Anaphylaxis and subsequent rhabdomyolysis induced by rifampin is an extremely rare event. It is necessary to initially prescribe low dose rifampin in cases of re-administration.

Keyword

Anaphylaxis; Rhabdomyolysis; Rifampin

MeSH Terms

Acute Kidney Injury
Adult
Anaphylaxis
Exanthema
Humans
Hypersensitivity
Critical Care
Lymphatic Diseases
Porphyrins
Rhabdomyolysis
Rifampin
Porphyrins
Rifampin