Allergy Asthma Respir Dis.  2016 May;4(3):212-216. 10.4168/aard.2016.4.3.212.

Rapid desensitization to isoniazid and rifampin in an adolescent with active pulmonary tuberculosis

• Lee H
• Kim MS
• Yang HK
• Kim M
• Lee JY
• Kim JM
• Kang JM
• Kim YJ
• Ahn K
• Kim J

• KMID: 2165084
• DOI: http://doi.org/10.4168/aard.2016.4.3.212

Abstract

Hypersensitivity reactions to antituberculosis medicine are obstacles to the treatment of tuberculosis. However, rapid drug desensitization can secure successful treatment with essential antituberculosis medicines in pediatric patients. A 17-year-old boy with active pulmonary tuberculosis complained of generalized erythematous rashes, pruritus on the 11th day of tuberculosis treatment. He was diagnosed with hypersensitivity reactions to isoniazid and rifampin by the oral provocation test. After desensitization, the patient continued to take antituberculosis treatment with isoniazid, rifampin, pyrazinamide, and ethambutol. We report here a case of successful desensitization in an adolescent with hypersensitivity to isoniazid and rifampin.

Keyword

Immunologic desensitization; Antitubercular agents; Drug hypersensitivity

MeSH Terms

Adolescent*
Antitubercular Agents
Desensitization, Immunologic
Drug Hypersensitivity
Ethambutol
Exanthema
Humans
Hypersensitivity
Isoniazid*
Male
Pruritus
Pyrazinamide
Rifampin*
Tuberculosis
Tuberculosis, Pulmonary*
Antitubercular Agents
Ethambutol
Isoniazid
Pyrazinamide
Rifampin

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