Korean J Med.  2012 Jan;82(1):73-77.

A Case of Long-Segment Barrett's Esophagus with Mixed Connective Tissue Disease

• Mun JI
• Kim DH
• Koo JH
• Kim IS
• Lee KJ

Abstract

Barrett's esophagus is a metaplasia of the esophageal epithelium of any length, such that normal squamous epithelium is replaced by specialized columnar epithelium with goblet cells. It is important to diagnose and survey Barrett's esophagus because it is believed to be the major risk factor for development of esophageal adenocarcinoma. However, the prevalence of Barrett's esophagus in Korea is low. Mixed connective tissue disease (MCTD) is a systemic disorder in which patients have combinations of the clinical features of systemic lupus erythematosus, systemic sclerosis, and polymyositis. Although gastroesophageal reflux disease is common in esophageal involvement in MCTD, long-segment Barrett's esophagus in MCTD has not been reported in Korea. We report here a 15 cm-long segment of Barrett's esophagus extending to the proximal esophagus in a female patient who has had MCTD for 2 years, and we review the literature.

Keyword

Barrett's esophagus; Scleroderma; Systemic; Mixed connective tissue disease

MeSH Terms

Adenocarcinoma
Barrett Esophagus
Epithelium
Esophagus
Female
Gastroesophageal Reflux
Goblet Cells
Humans
Korea
Lupus Erythematosus, Systemic
Metaplasia
Mixed Connective Tissue Disease
Polymyositis
Prevalence
Risk Factors
Scleroderma, Systemic