Korean J Med.  2011 Oct;81(4):533-536.

Systemic Lupus Erythematosus Preceded by Distal Renal Tubular Acidosis

Affiliations
  • 1Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea. ymkang@knu.ac.kr

Abstract

Distal renal tubular acidosis (RTA) is characterized by a decreased net H+ secretion in the collecting tubules, which results in a failure of urine acidification and results in metabolic acidosis, hypokalemia, and nephrocalcinosis. The acquired form of distal RTA is associated with tubulointerstitial involvement of immune-mediated disorders such as Sjogren's syndrome and systemic lupus erythematosus (SLE). Only a few case reports have indicated that distal RTA precedes SLE by months to years. We present a 39-year-old woman who had manifestations of distal RTA for 21 years before the development of overt symptoms of SLE.

Keyword

Lupus Erythematosus, Systemic; Acidosis, Renal Tubular; Tubulointestitial nephritis

MeSH Terms

Acidosis
Acidosis, Renal Tubular
Adult
Female
Humans
Hypokalemia
Lupus Erythematosus, Systemic
Nephrocalcinosis
Sjogren's Syndrome
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