Korean J Med.
2012 Jul;83(1):136-140.
A Case of Hypersensitivity Reaction Induced by Abacavir in an AIDS Patient
- Affiliations
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- 1Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea. cadevar@paran.com
- 2Department of Laboratory Medicine, Jeju National University School of Medicine, Jeju, Korea.
- 3Department of Dermatology, Jeju National University School of Medicine, Jeju, Korea.
Abstract
- Abacavir is a nucleoside reverse transcriptase inhibitor that is commonly used in HIV-infected patients. A well-known and potentially life-threatening side effect of abacavir is allergic hypersensitivity reaction. A screening test for the HLA-B*5701 allele is currently used to predict the risk of hypersensitivity reaction to abacavir. This test, however, may be less useful in Korea, because of the low prevalence of HLA-B*5701. A 52-year-old male with HIV infection was referred to our hospital because of suspected side-effects of antiviral agents and lymph node enlargement of the neck. He suffered from a fever, generalized edema, skin rash of the whole body, and difficulty breathing after starting antiviral agents. Suspected as a hypersensitivity reaction resulting from drug side-effects, prescription of abacavir was stopped. The patient subsequently recovered. The presence of the HLA-B*5701 allele was confirmed by polymerase chain reaction-sequencing based typing (PCR-SBT).
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