Korean J Obstet Gynecol.
2002 May;45(5):888-893.
Poorly Differentiated Endometrial Adenocarcinoma with Trophoblastic Differentiation
- Affiliations
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- 1Department of Obstetrics and Gynecology, Ewha Womans University College of Medicine, Seoul, Korea.
- 2Department of Pathology, Ewha Womans University College of Medicine, Seoul, Korea.
Abstract
- Trophoblastic differentiation in gynecologic nontrophoblastic tumor is very rare. Here we present a 66-year-old female with poorly differentiated endometrial carcinoma showing trophoblast-like differentiation. This tumor was in advanced stage with metastases to lung, liver, and bone at diagnosis. The multinucleated, syncytiotrophoblast-like cells were positive for beta-human chorionic gonadotropin (beta-hCG) by immunochemical stain. The level of beta-hCG was also elevated (219 mIU/ml) in the patient's serum, but dropped after surgery and chemotherapy. beta-hCG may be used as tumor marker in this case.
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