Korean J Obstet Gynecol.
2002 Mar;45(3):399-403.
Cyclooxygenase-2 Expression and Angiogenesis in Invasive Cervical Cancer
- Affiliations
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- 1Department of Obstetrics and Gynecology, College of Medicine, Hallym University, Korea.
- 2Department of Pathology, College of Medicine, Hallym University, Korea.
Abstract
OBJECTIVE
A large body of evidence suggests that cyclooxygenase-2 (COX-2) is important in tumor growth and angiogenesis of gastrointestinal and other cancers. This was the study to determine the relationship between tumor vascularity and COX-2 expression in invasive cervical cancer.
METHODS
We examined the expression of COX-2 and microvessel density (MVD) by immunohis- tochemical staining in 21 specimens collected from invasive cervical cancer patients.
RESULTS
All specimens showed weak and strong immunoreactivity, with 52.4% strong reactivity. Microvessel count was higher (median 136) in the strong COX-2 immunoreactivity specimens than the weaks (median 90), and MVD was significantly correlated with the COX-2 immunoreactivity (P=0.002).
CONCLUSION
These preliminary data indicate that overexpression of COX-2 may play an important role in carcinogenesis of cervical cancer and this could be partially attributable to modulation of angiogenesis by COX-2. COX-2 maybe a target for future research in the tumorigenesis of the invasive cervical cancer.
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